THE MOLECULAR-BASIS OF FRAGILE SITES IN HUMAN-CHROMOSOMES

被引：90

作者：

SUTHERLAND, GR

RICHARDS, RI

机构：

[1] Centre for Medical Genetics, Department of Cytogenetics and Molecular Genetics, Women's and Children's Hospital, Adelaide

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1995年 / 5卷 / 03期

关键词：

D O I：

10.1016/0959-437X(95)80046-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Fragile sites on chromosomes have been classified into a number of groups according to their frequency and the conditions required to induce them. A number of the rare folate-sensitive fragile sites have been characterized and shown to be amplified methylated CCG trinucleotide repeats. One common fragile site has been partly characterized and appears to be a region of fragility, rather than a single site.

引用

页码：323 / 327

页数：5

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