Bacterial superantigens in human disease: Structure, function and diversity

被引：49

作者：

Ulrich, RG

Bavari, S

Olson, MA

机构：

[1] USA, MED RES INST INFECT DIS, DEPT IMMUNOL & MOLEC BIOL, FREDERICK, MD 21701 USA

[2] USA, MED RES INST INFECT DIS, DEPT CELL BIOL & BIOCHEM, FREDERICK, MD 21701 USA

来源：

TRENDS IN MICROBIOLOGY | 1995年 / 3卷 / 12期

关键词：

D O I：

10.1016/S0966-842X(00)89011-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

All bacterial superantigens use common structural strategies to bind to major histocompatibility complex class II receptors, while binding the T cell antigen receptor in different ways. Overstimulation of the immune response is responsible for the acute pathological effects, while reactivation of developmentally silenced T cells might result in autoimmune disease. Certain diseases might be controlled with superantigens or genetically attenuated vaccines.

引用

收藏

页码：463 / 468

页数：6

相关论文

共 51 条

[1] LIMITED HETEROGENEITY OF T-CELL RECEPTORS FROM LYMPHOCYTES MEDIATING AUTOIMMUNE ENCEPHALOMYELITIS ALLOWS SPECIFIC IMMUNE INTERVENTION [J].

ACHAORBEA, H ;

MITCHELL, DJ ;

TIMMERMANN, L ;

WRAITH, DC ;

TAUSCH, GS ;

WALDOR, MK ;

ZAMVIL, SS ;

MCDEVITT, HO ;

STEINMAN, L .

CELL, 1988, 54 (02) :263-273

[2] STRUCTURAL BASIS OF SUPERANTIGEN ACTION INFERRED FROM CRYSTAL-STRUCTURE OF TOXIC-SHOCK SYNDROME TOXIN-1 [J].

ACHARYA, KR ;

PASSALACQUA, EF ;

JONES, EY ;

HARLOS, K ;

STUART, DI ;

BREHM, RD ;

TRANTER, HS .

NATURE, 1994, 367 (6458) :94-97

[3] PENICILLINASE PLASMID-LINKED GENETIC-DETERMINANTS FOR ENTEROTOXIN-B AND ENTEROTOXIN-C1 PRODUCTION IN STAPHYLOCOCCUS-AUREUS [J].

ALTBOUM, Z ;

HERTMAN, I ;

SARID, S .

INFECTION AND IMMUNITY, 1985, 47 (02) :514-521

[4] THE MYCOPLASMA-ARTHRITIDIS SUPERANTIGEN MAM - PURIFICATION AND IDENTIFICATION OF AN ACTIVE PEPTIDE [J].

ATKIN, CL ;

WEI, SH ;

COLE, BC .

INFECTION AND IMMUNITY, 1994, 62 (12) :5367-5375

[5] DIVERGENCE OF HUMAN AND NONHUMAN PRIMATE LYMPHOCYTE-RESPONSES TO BACTERIAL SUPERANTIGENS [J].

BAVARI, S ;

HUNT, RE ;

ULRICH, RG .

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1995, 76 (03) :248-254

[6] STAPHYLOCOCCAL-ENTEROTOXIN-A AND TOXIC-SHOCK-SYNDROME TOXIN COMPETE WITH CD4 FOR HUMAN MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II BINDING [J].

BAVARI, S ;

ULRICH, RG .

INFECTION AND IMMUNITY, 1995, 63 (02) :423-429

[7]

BAVARI S, 1995, J CELL BIOCH A S, V21, P88

[8] GENETIC AND MOLECULAR ANALYSES OF THE GENE ENCODING STAPHYLOCOCCAL ENTEROTOXIN-D [J].

BAYLES, KW ;

IANDOLO, JJ .

JOURNAL OF BACTERIOLOGY, 1989, 171 (09) :4799-4806

[9] COMBINED ACTIVATION OF MURINE LYMPHOCYTES WITH STAPHYLOCOCCAL-ENTEROTOXIN AND INTERLEUKIN-2 RESULTS IN ADDITIVE CYTOTOXIC ACTIVITY [J].

BELFRAGE, H ;

BHILADVALA, P ;

HEDLUND, G ;

DOHLSTEN, M ;

KALLAND, T .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 1994, 38 (04) :265-271

[10] CASE-REPORT - STREPTOCOCCAL TOXIC SHOCK SYNDROME PRESENTING AS SEPTIC THROMBOPHLEBITIS IN A CHILD WITH VARICELLA [J].

COHENABBO, A ;

HARPER, MB .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1993, 12 (12) :1033-1034

← 1 2 3 4 5 6 →