FIBROBLAST GROWTH-FACTOR RECEPTOR IS A PORTAL OF CELLULAR ENTRY FOR HERPES-SIMPLEX VIRUS TYPE-1

被引：121

作者：

KANER, RJ

BAIRD, A

MANSUKHANI, A

BASILICO, C

SUMMERS, BD

FLORKIEWICZ, RZ

HAJJAR, DP

机构：

[1] CORNELL UNIV, MED CTR, COLL MED, DEPT BIOCHEM, NEW YORK, NY 10021 USA

[2] CORNELL UNIV, MED CTR, COLL MED, DEPT PATHOL, NEW YORK, NY 10021 USA

[3] MEM SLOAN KETTERING CANC CTR, DEPT MED, NEW YORK, NY 10021 USA

[4] NYU, SCH MED, DEPT PATHOL, NEW YORK, NY 10016 USA

[5] WHITTIER INST DIABET & ENDOCRINOL, DEPT MOLEC & CELLULAR GROWTH BIOL, LA JOLLA, CA 92037 USA

来源：

SCIENCE | 1990年 / 248卷 / 4961期

关键词：

D O I：

10.1126/science.2162560

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Herpes simplex virus type 1 (HSV-1) is a ubiquitous pathogen responsible for considerable morbidity in the general population. The results presented herein establish the basic fibroblast growth factor (FGF) receptor as a means of entry of HSV-1 into vertebrate cells. Inhibitors of basic FGF binding to its receptor and competitive polypeptide antagonists of basic FGF prevented HSV-1 uptake. Chinese hamster ovary (CHO) cells that do not express FGF receptors are resistant to HSV-1 entry; however, HSV-1 uptake is dramatically increased in CHO cells transfected with a complementary DNA encoding a basic FGF receptor. The distribution of this integral membrane protein in vivo may explain the tissue and cell tropism of HSV-1.

引用

页码：1410 / 1413

页数：4

共 49 条

[1] FIBROBLAST GROWTH-FACTORS [J].