SENSITIVITY OF T-CELLS TO ANTI-CD3-STIMULATED SUICIDE IS INDEPENDENT OF FUNCTIONAL PHENOTYPE

被引：55

作者：

RUSSELL, JH

RUSH, BJ

ABRAMS, SI

WANG, R

机构：

[1] Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1992年 / 22卷 / 06期

关键词：

D O I：

10.1002/eji.1830220648

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have examined mixed populations and cloned murine CD4+ T cell lines for their sensitivity to anti-CD3-stimulated suicide. The sensitivity of CD4+ clones to anti-CD3-stimulated suicide is independent of their interleukin-2/interleukin-4 or interferon-gamma secretion profile or their lytic efficiency in anti-CD3 redirected lytic assays.

引用

收藏

页码：1655 / 1658

页数：4

相关论文

共 30 条

[1] T-CELL TUMOR ELIMINATION AS A RESULT OF T-CELL RECEPTOR MEDIATED ACTIVATION [J].

ASHWELL, JD ;

LONGO, DL ;

BRIDGES, SH .

SCIENCE, 1987, 237 (4810) :61-64

[2]

AWATSON J, 1909, J EXP MED, V150, P1540

[3]

BRUCE J, 1981, J IMMUNOL, V127, P2496

[4] EXPRESSION OF INTERLEUKIN-2 RECEPTORS AS A DIFFERENTIATION MARKER ON INTRATHYMIC STEM-CELLS [J].

CEREDIG, R ;

LOWENTHAL, JW ;

NABHOLZ, M ;

MACDONALD, HR .

NATURE, 1985, 314 (6006) :98-100

[5]

CROSSLAND KD, 1991, J IMMUNOL, V146, P4414

[6] CHARACTERIZATION OF THE MURINE ANTIGENIC DETERMINANT, DESIGNATED L3T4A, RECOGNIZED BY MONOCLONAL-ANTIBODY GK1.5 - EXPRESSION OF L3T4A BY FUNCTIONAL T-CELL CLONES APPEARS TO CORRELATE PRIMARILY WITH CLASS II MHC ANTIGEN-REACTIVITY [J].

DIALYNAS, DP ;

WILDE, DB ;

MARRACK, P ;

PIERRES, A ;

WALL, KA ;

HAVRAN, W ;

OTTEN, G ;

LOKEN, MR ;

PIERRES, M ;

KAPPLER, J ;

FITCH, FW .

IMMUNOLOGICAL REVIEWS, 1983, 74 :29-56

[7]

JANSSEN O, 1991, J IMMUNOL, V146, P35

[8]

JONES LA, 1990, SCIENCE, V250, P4988

[9] RAPID METHOD FOR ISOLATION OF FUNCTIONAL THYMUS-DERIVED MURINE LYMPHOCYTES [J].

JULIUS, MH ;

SIMPSON, E ;

HERZENBERG, LA .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1973, 3 (10) :645-649

[10] SELF-TOLERANCE ELIMINATES T-CELLS SPECIFIC FOR MLS-MODIFIED PRODUCTS OF THE MAJOR HISTOCOMPATIBILITY COMPLEX [J].

KAPPLER, JW ;

STAERZ, U ;

WHITE, J ;

MARRACK, PC .

NATURE, 1988, 332 (6159) :35-40