TRACE ELEMENT-GENE INTERACTIONS

For many of the genes encoding proteins involved in the transport, storage, and function of the trace elements, expression is regulated by the availability of the elements concerned. This control is exercised through a variety of mechanisms, including metal-activated transcription factors, modified usage of stop codons, and use of secondary structure within mRNA to regulate its translation and stability. Two widely represented groups of transcription factors, often classed as zinc-finger proteins, depend on constituent zinc ions for their activity. In addition, the sensitivity of growth and fetal development to the lack of zinc is hypothesized to relate to a requirement for the element during certain critical alterations in gene expression. The evidence for this and possible underlying mechanisms is examined.