MICROGLIAL CELL UP-REGULATION OF HIV-1 EXPRESSION IN THE CHRONICALLY INFECTED PROMONOCYTIC CELL-LINE U1 - THE ROLE OF TUMOR-NECROSIS-FACTOR-ALPHA

被引：25

作者：

PETERSON, PK

GEKKER, G

HU, SX

SCHOOLOV, Y

BALFOUR, HH

CHAO, CC

机构：

[1] MINNEAPOLIS MED RES FDN INC,NEUROIMMUNOBIOL & HOST DEF LAB,MINNEAPOLIS,MN

[2] UNIV MINNESOTA,HLTH SCI CTR,DEPT PATHOL,MINNEAPOLIS,MN 55455

[3] UNIV MINNESOTA,HLTH SCI CTR,DEPT LAB MED,MINNEAPOLIS,MN 55455

[4] UNIV MINNESOTA,SCH MED,MINNEAPOLIS,MN 55455

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1992年 / 41卷 / 01期

关键词：

MICROGLIA; HUMAN IMMUNODEFICIENCY VIRUS-1; PROMONOCYTE; TUMOR NECROSIS FACTOR-ALPHA; PENTOXIFYLLINE;

D O I：

10.1016/0165-5728(92)90198-T

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Culture supernatants from lipopolysaccharide (LPS)-treated murine microglial cells were found to markedly induce the expression of human immunodeficiency virus (HIV)-1 in the chronically infected human promonocytic cell line U1 as detected by measurements of HIV-1 p24 antigen release into U1 culture supernatants. Antibody to tumor necrosis factor (TNF)-alpha had an inhibitory effect on the induction of virus by microglial cell supernatants. Also, treatment of microglia with pentoxifylline, an inhibitor of TNF-alpha production, resulted in suppressed amounts of TNF in the supernatants of LPS-treated microglia and in a reduced stimulatory capacity of these supernatants on HIV-1 expression in U1 cells. These findings support the concept that TNF-alpha production by glial cells plays a pathogenetic role in HIV-1-associated brain disease by promoting the expression of the virus in infected cells.

引用

页码：81 / 87

页数：7

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