STUDIES ON ANABOLIC-STEROIDS .9. TERTIARY SULFATES OF ANABOLIC 17-ALPHA-METHYL STEROIDS - SYNTHESIS AND REARRANGEMENT

被引：32

作者：

BI, HG

MASSE, R

JUST, G

机构：

[1] UNIV QUEBEC,INST NATL RECH SCI SANTE,245 HYMUS BLVD,POINTE CLAIRE H9R 1G6,QUEBEC,CANADA

[2] MCGILL UNIV,DEPT CHEM,MONTREAL H3A 2T5,QUEBEC,CANADA

来源：

STEROIDS | 1992年 / 57卷 / 07期

基金：

加拿大自然科学与工程研究理事会;

关键词：

STEROIDS; TERTIARY SULFATES; 17-ALPHA-METHYL STEROIDS; 17-BETA-METHYL STEROIDS; 17,17-DIMETHYL-18-NORANDROST-13(14)-ENES; NMR;

D O I：

10.1016/0039-128X(92)90048-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A simple and convenient method has been developed to prepare sulfates of anabolic 17-beta-hydroxy-17-alpha-methyl steroids. The sulfates of methandienone, 17-alpha-methyltestosterone, mestanolone, oxandrolone, and stanozolol were prepared. Different A-ring functions were not affected under the sulfation condition. The buffered hydrolyses of these sulfates provided the 17-epimers of the original steroids and 17, 17-dimethyl-18-nor-13(14)-ene steroids, presumably via the 17-carbocations.

引用

页码：306 / 312

页数：7

共 20 条

[1] C-13 NMR-STUDIES .69. C-13 NMR-SPECTRA OF STEROIDS - SURVEY AND COMMENTARY [J].