ASSESSING RESPONSE TO TACRINE USING THE FACTOR-ANALYTIC STRUCTURE OF THE ALZHEIMERS-DISEASE ASSESSMENT SCALE (ADAS) COGNITIVE SUBSCALE

被引：18

作者：

OLIN, JT

SCHNEIDER, LS

机构：

[1] UNIV SO CALIF, SCH MED, DEPT PSYCHIAT & BEHAV SCI, LOS ANGELES, CA 90033 USA

[2] UNIV SO CALIF, SCH GERONTOL, DEPT NEUROL, LOS ANGELES, CA USA

来源：

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY | 1995年 / 10卷 / 09期

关键词：

ALZHEIMERS DISEASE ASSESSMENT SCALE; DEMENTIA; COGNITION; MEMORY TESTS;

D O I：

10.1002/gps.930100905

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 [法学]; 0303 [社会学]; 100203 [老年医学];

摘要：

A factor analysis of the Alzheimer's Disease Assessment Scale-Cognitive subscale (ADASc), the primary cognitive outcome measure in most clinical trials of drugs for Alzheimer's disease, was undertaken to test whether factor scores are differentially sensitive to change in a placebo-controlled 30-week trial of the cholinesterase inhibitor tacrine. The factor analysis identified three factors: language, memory and praxis, a factor structure similar to an earlier report. All three factors showed worsening for placebo patients acid improvements for tacrine patients, with significant between-group treatment effects. None of the factors was significantly more sensitive to change than another, suggesting that tacrine affects a range of cognitive function.

引用

页码：753 / 756

页数：4

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