Human pancreatic cancer-associated stellate cells remain activated after in vivo chemoradiation

被引：26

作者：

Cabrera, M. Carla ^{[1
,2
]}

Tilahun, Estifanos ^{[2
]}

Nakles, Rebecca ^{[2
]}

Diaz-Cruz, Edgar S. ^{[2
,3
]}

Charabaty, Aline ^{[4
]}

Suy, Simeng ^{[2
,5
]}

Jackson, Patrick ^{[6
]}

Ley, Lisa ^{[2
]}

Slack, Rebecca ^{[7
]}

Jha, Reena ^{[8
]}

Collins, Sean P. ^{[2
,5
]}

Haddad, Nadim ^{[4
]}

Kallakury, Bhaskar V. S. ^{[2
,9
]}

Schroeder, Timm ^{[10
,11
]}

Pishvaian, Michael J. ^{[2
,4
,12
]}

Furth, Priscilla A. ^{[2
,12
]}

机构：

[1] NCI, Natl Canc Informat Program, NIH, Bethesda, MD 20892 USA

[2] Georgetown Univ, Dept Oncol, Lombardi Comprehens Canc Ctr, Washington, DC USA

[3] Belmont Univ, Coll Pharm, Dept Pharmaceut Sci, Nashville, TN USA

[4] Georgetown Univ, Dept Gastroenterol, Washington, DC USA

[5] Georgetown Univ, Dept Radiat Med, Washington, DC USA

[6] Georgetown Univ, Dept Surg, Washington, DC USA

[7] Univ Texas MD Anderson Canc Ctr, Dept Biostat, Houston, TX 77030 USA

[8] Georgetown Univ, Dept Radiol, Washington, DC USA

[9] Georgetown Univ, Dept Pathol, Washington, DC USA

[10] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Res Unit Stem Cell Dynam, Neuherberg, Germany

[11] Swiss Fed Inst Technol, Dept Biosyst Sci & Engn, Basel, Switzerland

[12] Georgetown Univ, Dept Med, Div Hematol Oncol, 3970 Reservoir Rd North West,Res Bldg,Room 520A, Washington, DC 20057 USA

来源：

FRONTIERS IN ONCOLOGY | 2014年 / 4卷

关键词：

pancreatic cancer; stellate cells; chemotherapy; radiation; gemcitabine; PDAC;

D O I：

10.3389/fonc.2014.00102

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extensive fibrotic reaction or desmoplasia and complex involvement of the surrounding tumor microenvironment. Pancreatic stellate cells are a key mediator of the pancreatic matrix and they promote progression and invasion of pancreatic cancer by increasing cell proliferation and offering protection against therapeutic interventions. Our study utilizes human tumor-derived pancreatic stellate cells (HTPSCs) isolated from fine needle aspirates of pancreatic cancer tissue from patients with locally advanced, unresectable pancreatic adenocarcinoma before and after treatment with full-dose gemcitabine plus concurrent hypo-fractionated stereo tactic radiosurgery. We show that HTPSCs survive in vivo chemotherapy and radiotherapy treatment and display a more activated phenotype post-therapy. These data support the idea that stellate cells play an essential role in supporting and promoting pancreatic cancer and further research is needed to develop novel treatments targeting the pancreatic tumor microenvironment.

引用

页数：8

共 42 条

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