RATES OF LIPOGENESIS AND PLASMA-INSULIN CONCENTRATIONS IN INBRED LINES OF MICE DIFFERING IN FATNESS

Rates of lipogenesis de novo and plasma concentrations of insulin were compared during post-natal growth in two inbred lines of mice (VL/fDk (VL) and SWR/fNIMR (SWR)) in which differences in growth and fatness are probably due to multiple not single gene effects. Irrespective of sex, the lipogenic rate g was higher in the fatter VL mice in the liver and all other tissues except the head, where it was lower, and the gonadal fat pad, where it was not different. Adult mice in general had lower lipogenic rates than those measured soon after weaning. In both lines the lipogenic rate g of tissue was higher in males in the liver and in females in the gonadal fat pad. Plasma insulin concentrations were higher in VL mice and tended to rise with age. These results demonstrate that metabolic differences associated with differences in fatness in inbred lines of mice in which fatness is controlled by more than one gene, are qualitatively but not quantitatively similar to those observed by other workers in lines of mice differing in fatness due to a single gene mutation. © 1990.