DELAYED REPLICATION OF XQ27 IN INDIVIDUALS WITH THE FRAGILE X-SYNDROME

被引：28

作者：

WEBB, T

机构：

[1] West Midlands Regional Genetics Svc., Dept. of Clinical Genetics, Birmingham Maternity Hospital

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS | 1992年 / 43卷 / 06期

关键词：

D O I：

10.1002/ajmg.1320430633

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The timing of late replicating bands on the X chromosome has been studied in individuals with the fragile X [fra (X)] syndrome. Compared to controls both affected individuals and symptomless carriers of the syndrome show delayed replication of the Xq27 region as shown by 2 different methods. The implications of this finding are discussed in relation to the proposal [Laird et al., 1987] that the fraX syndrome is associated with a failure to reactivate the Xq27 band correctly after it has been inactivated in a female.

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页码：1057 / 1062

页数：6

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