POTENTIAL-DEPENDENT ALPHA-LATROTOXIN INTERACTION WITH BLACK LIPID-MEMBRANES

被引:6
作者
CHANTURIA, AN [1 ]
LISHKO, VK [1 ]
机构
[1] AV PALLADIN BIOCHEM INST,DEPT NEUROCHEM,KIEV 252030,UKRAINE,USSR
关键词
D O I
10.1016/0041-0101(92)90051-6
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The influence of membrane potential on alpha-latrotoxin insertion into bilayer lipid membranes (BLM) has been investigated. It was found that positive potentials cis to toxin application stimulated the formation of channels in the bilayer. A two-step model of latrotoxin/membrane interaction is put forward to explain these data. In the first step, latrotoxin irreversibly binds to the bilayer without forming conductive structures. The second step of the process represents rapid insertion of the protein molecule into the bilayer with the formation of the conducting channel. We imagine the driving force for this process to be the interaction of charged groups' in the toxin molecule with the electric field applied across the BLM. Our results are compared with known data on the interaction of LTX with synaptosomal membranes.
引用
收藏
页码:1059 / 1064
页数:6
相关论文
共 17 条
[1]   EFFECTS OF POTASSIUM, VERATRIDINE AND SCORPION-VENOM ON CALCIUM ACCUMULATION AND TRANSMITTER RELEASE BY NERVE-TERMINALS INVITRO [J].
BLAUSTEIN, MP .
JOURNAL OF PHYSIOLOGY-LONDON, 1975, 247 (03) :617-655
[2]   VOLTAGE-DEPENDENT ORIENTATION OF MEMBRANE-PROTEINS [J].
BLUMENTHAL, R ;
KEMPF, C ;
VANRENSWOUDE, J ;
WEINSTEIN, JN ;
KLAUSNER, RD .
JOURNAL OF CELLULAR BIOCHEMISTRY, 1983, 22 (01) :55-67
[3]  
CHANTURIA AN, 1985, DOKL AKAD NAUK UKR S, V9, P82
[4]   DETECTION OF TRANSIENT CAPACITANCE INCREASE ASSOCIATED WITH CHANNEL FORMATION IN LIPID BILAYERS [J].
CHANTURIYA, AN .
BIOCHIMICA ET BIOPHYSICA ACTA, 1990, 1026 (02) :248-250
[5]   MECHANISMS OF MEMBRANE ASSEMBLY - EFFECTS OF ENERGY POISONS ON THE CONVERSION OF SOLUBLE M13-COLIPHAGE PROCOAT TO MEMBRANE-BOUND COAT PROTEIN [J].
DATE, T ;
ZWIZINSKI, C ;
LUDMERER, S ;
WICKNER, W .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (02) :827-831
[6]  
DUGLEBY RG, 1981, ANAL BIOCHEM, V110, P9
[7]   BLACK-WIDOW SPIDER VENOM - EFFECT OF PURIFIED TOXIN ON LIPID BILAYER MEMBRANES [J].
FINKELSTEIN, A ;
RUBIN, LL ;
TZENG, MC .
SCIENCE, 1976, 193 (4257) :1009-1011
[8]   BIOGENESIS OF CYTOCHROME-C IN NEUROSPORA-CRASSA - SYNTHESIS OF APOCYTOCHROME-C, TRANSFER TO MITOCHONDRIA AND CONVERSION TO HOLOCYTOCHROME-C [J].
KORB, H ;
NEUPERT, W .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1978, 91 (02) :609-620
[9]  
MCCECCHINI ML, 1979, P NATL ACAD SCI USA, V76, P4365
[10]   THE EFFECT OF ALPHA-LATROTOXIN ON THE NEUROSECRETORY PC12-CELL LINE - STUDIES ON TOXIN BINDING AND STIMULATION OF TRANSMITTER RELEASE [J].
MELDOLESI, J ;
MADEDDU, L ;
TORDA, M ;
GATTI, G ;
NIUTTA, E .
NEUROSCIENCE, 1983, 10 (03) :997-1009