AUTOLOGOUS BLOOD STEM-CELL TRANSPLANTATION IN PEDIATRIC CANCER-PATIENTS - THE AUSTRIAN EXPERIENCE (1986-1991)

被引：4

作者：

EMMINGER, W ^{[1
]}

HOCKER, P ^{[1
]}

EMMINGERSCHMIDMEIER, W ^{[1
]}

FRITSCH, G ^{[1
]}

PETERS, C ^{[1
]}

GERHARTL, C ^{[1
]}

HAAS, OA ^{[1
]}

AMBROS, P ^{[1
]}

MENZGATTERER, I ^{[1
]}

GADNER, H ^{[1
]}

机构：

[1] INTENS BLOOD BANK,VIENNA,AUSTRIA

来源：

INTERNATIONAL JOURNAL OF CELL CLONING | 1992年 / 10卷

关键词：

BLOOD STEM CELL AUTOGRAFTING (ABSCT); CHILDREN; SOLID TUMORS; HEMATOLOGIC MALIGNANCIES;

D O I：

10.1002/stem.5530100752

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 0836 [生物工程]; 090102 [作物遗传育种]; 100705 [微生物与生化药学];

摘要：

Autologous blood stem cell transplantation (ABSCT) was applied in 29 children with advanced malignant disease (generalised solid tumors or hematologic malignancies). The median age was 12 years. We observed up to median 40fold increases in the myeloid committed progenitors (CFU-GM) and numbers of hematopoietic progenitors obtained after myeloablative therapy. The determination of CD34 positive cells by flow cytometry appeared to be helpful to determine the optimal days for leukaphereses. Granulocyte recovery was rapid after ABSCT with 11 days (8-17) to reach 0.1 x 10(9)/1 granulocytes and 23 days (11-214) to 1 x 10(9)/1 circulating lymphocytes. Eleven of 29 children are alive in complete remission for median 27 months (range 3-57) after ABSCT.

引用

页码：157 / 159

页数：3