PROGNOSTIC RELEVANCE OF PS2-STATUS IN ASSOCIATION WITH STEROID-RECEPTOR STATUS AND PROLIFERATIVE ACTIVITY IN NODE-NEGATIVE BREAST-CANCER

被引：41

作者：

CAPPELLETTI, V

CORADINI, D

SCANZIANI, E

BENINI, E

SILVESTRINI, R

DIFRONZO, G

机构：

[1] IST NAZL TUMORI,VIA VENEZIAN 1,I-20133 MILAN,ITALY

[2] CNR,CTR STUDIO PATOL CELLULARE,I-20133 MILAN,ITALY

[3] IST ANAT PATOL VET & PATOL AVIARE,MILAN,ITALY

来源：

EUROPEAN JOURNAL OF CANCER | 1992年 / 28A卷 / 8-9期

关键词：

D O I：

10.1016/0959-8049(92)90507-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Expression of the oestrogen-regulated pS2 protein was investigated on paraffin-embedded sections of primary breast tumours from 200 node-negative patients. Immunoreactivity was observed in 56% of the cases. pS2 expression was inversely correlated with tumour size and proliferative activity, whereas a direct correlation was observed with steroid receptor. 5-year relapse free survival was influenced by tumour size (P = 0.02), oestrogen receptor status (P < 0.05), and proliferative activity (P < 0.01). No difference in relapse-free survival was observed between patients subdivided according to pS2 expression alone. However, among patients with oestrogen-receptor-negative tumors, pS2 expression predicted a shorter relapse-free survival.

引用

页码：1315 / 1318

页数：4

共 17 条

[1]

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