INHIBITION OF THE MITOCHONDRIAL CALCIUM UNIPORTER BY ANTIBODIES AGAINST A 40-KDA GLYCOPROTEIN(T)

被引：27

作者：

SARIS, NEL

SIROTA, TV

VIRTANEN, I

NIVA, K

PENTTILA, T

DOLGACHOVA, LP

MIRONOVA, GD

机构：

[1] RUSSIAN ACAD SCI, INST THEORET & EXPTL BIOPHYS, PUSHCHINO, RUSSIA

[2] RUSSIAN ACAD SCI, INST THEORET & EXPTL BIOPHYS, MOSCOW, RUSSIA

[3] UNIV HELSINKI, DEPT ANAT, SF-00100 HELSINKI 10, FINLAND

来源：

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES | 1993年 / 25卷 / 03期

关键词：

CALCIUM TRANSPORT; FIBROBLAST; GLYCOPROTEIN; HEART; MITOCHONDRIA; SPERMINE; UNIPORTER;

D O I：

10.1007/BF00762591

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Polyclonal rabbit antibodies against a Ca2+-binding mitochondrial glycoprotein were found to inhibit the uniporter-mediated transport of Ca2+ in mitoplasts prepared from rat liver mitochondria. Spermine, a modulator of the uniporter, decreased the inhibition. This glycoprotein of M(r) 40,000, isolated from beef heart mitochondria and earlier shown to form Ca2+-conducting channels in black-lipid membranes, thus is a good candidate for being a component of the uniporter. Antibody-IgG was found to specifically bind to mitochondria in human fibroblasts.

引用

页码：307 / 312

页数：6

共 31 条

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