SYNTHESIS OF SOME PHOSPHONATES WITH ANTIHERPETIC ACTIVITY

被引：8

作者：

DIANA, GD ^{[1
]}

ZALAY, ES ^{[1
]}

SALVADOR, UJ ^{[1
]}

PANCIC, F ^{[1
]}

STEINBERG, B ^{[1
]}

机构：

[1] STERLING WINTHROP RES INST, RENSSELAER, NY 12144 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1984年 / 27卷 / 05期

关键词：

D O I：

10.1021/jm00371a024

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several keto phosphonates, phosphonoacetates and dialkyl phosphonates containing (aryloxy)aryl gorups were synthesized and evaluated for antiherpetic activity. Two of the most active compounds, 12 [ethyl 8-(2-chloro-4-methoxyphenoxy)-2-(diethoxyphosphinyl)octanoate] and 16 [diethyl [6-(2-chloro-4-methoxyphenoxy)hexyl]-phosphonate], were evaluated topically in the mouse vaginal model against herpes simplex virus (HSV) type 2. Compound 16 exhibited an increased survival rate, as well as increased survival time. Evaluation of 16 in the guinea pig skin test against HSV-2 produced a reduction in virus titer, as well as in mean vesicle score.

引用

页码：691 / 694

页数：4

共 12 条

[1] BOPP BA, 1977, FED PROC, V36, P939
[2] ANTI-VIRAL ACTIVITY OF SOME BETA-DIKETONES .3. ARYL BIS(BETA-DIKETONES) - ANTI-HERPETIC ACTIVITY
DIANA, GD
CARABATEAS, PM
SALVADOR, UJ
WILLIAMS, GL
ZALAY, ES
PANCIC, F
STEINBERG, BA
COLLINS, JC
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1978, 21 (07) : 689 - 692
[3] ANTI-VIRAL ACTIVITY OF SOME BETA-DIKETONES .2. ARYLOXY ALKYL DIKETONES - INVITRO ACTIVITY AGAINST BOTH RNA AND DNA VIRUSES
DIANA, GD
SALVADOR, UJ
ZALAY, ES
CARABATEAS, PM
WILLIAMS, GL
COLLINS, JC
PANCIC, F
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1977, 20 (06) : 757 - 761
[4] ANTI-VIRAL ACTIVITY OF SOME BETA-DIKETONES .4. BENZYL DIKETONES - INVITRO ACTIVITY AGAINST BOTH RNA AND DNA VIRUSES
DIANA, GD
CARABATEAS, PM
JOHNSON, RE
WILLIAMS, GL
PANCIC, F
COLLINS, JC
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1978, 21 (09) : 889 - 894
[5] ANTI-VIRAL ACTIVITY OF SOME BETA-DIKETONES .1. ARYL ALKYL DIKETONES - INVITRO ACTIVITY AGAINST BOTH RNA AND DNA VIRUSES
DIANA, GD
SALVADOR, UJ
ZALAY, ES
JOHNSON, RE
COLLINS, JC
JOHNSON, D
HINSHAW, WB
LORENZ, RR
THIELKING, WH
PANCIC, F
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1977, 20 (06) : 750 - 756
[6] SYNTHESIS AND ANTIHERPETIC ACTIVITY OF SOME 4-[(ARYLOXY)ALKYL]PYRAZOLES
DIANA, GD
CARABATEAS, PM
WILLIAMS, GL
PANCIC, F
STEINBERG, BA
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1981, 24 (06) : 731 - 735
[7] PYROPHOSPHATE ANALOGS AS INHIBITORS OF HERPES-SIMPLEX VIRUS TYPE-1 DNA-POLYMERASE
ERIKSSON, B
LARSSON, A
HELGSTRAND, E
JOHANSSON, NG
OBERG, B
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1980, 607 (01) : 53 - 64
[8] TRISODIUM PHOSPHONOFORMATE, A NEW ANTI-VIRAL COMPOUND
HELGSTRAND, E
ERIKSSON, B
JOHANSSON, NG
LANNERO, B
LARSSON, A
MISIORNY, A
NOREN, JO
SJOBERG, B
STENBERG, K
STENING, G
STRIDH, S
OBERG, B
ALENIUS, S
PHILIPSON, L
[J]. SCIENCE, 1978, 201 (4358) : 819 - 821
[9] MAY J, 1977, J ANTIMICROB CHEMOTH, V11, P919
[10] PALMER AE, 1978, J ANTIMICROB CHEMOTH, V12, P510

← 1 2 →