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THE ROLE OF GLUCOCORTICOIDS IN THE REGULATION OF GROWTH-HORMONE SECRETION - MECHANISMS AND CLINICAL-SIGNIFICANCE

被引：107
作者：
GIUSTINA, A [1 ]
WEHRENBERG, WB [1 ]
机构：
[1] UNIV BRESCIA,DEPT CLIN MED,BRESCIA,ITALY
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1992年 / 3卷 / 08期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/1043-2760(92)90142-N
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Glucocorticoids are well known to inhibit growth and GH secretion in humans and animals, yet in vitro these steroids stimulate GH synthesis and secretion. These opposite actions appear to be mediated at different sites. The inhibition involves modulation of hypothalamic somatostatin and the stimulation involves direct actions on the pituitary. Current evidence suggests that the predominant action in vivo is through the inhibitory influences of somatostatin.
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页码：306 / 311
页数：6
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