INVITRO TYROSINE PHOSPHORYLATION OF PLC-GAMMA-1 AND PLC-GAMMA-2 BY SRC-FAMILY PROTEIN TYROSINE KINASES

被引：85

作者：

LIAO, F ^{[1
]}

SHIN, HS ^{[1
]}

RHEE, SG ^{[1
]}

机构：

[1] NHLBI, BIOCHEM LAB, BETHESDA, MD 20892 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 191卷 / 03期

关键词：

D O I：

10.1006/bbrc.1993.1320

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The phosphorylation of purified phospholipase C-γ1 (PLC-γ1) and PLC-γ2 by src-family-protein tyrosine kinases (PTKs) P56lck, p53/56lyn, p59hck, p59fyn, and p60src was studied in vitro. All five PTKs phosphorylated PLC-γ1 and PLC-γ2, suggesting that both PLC-γ isozymes can be phosphorylated in cells by any of the src-family PTKs in response to the activation of cell surface receptors. Comparison of the in vitro phosphorylation rates revealed no distinct specificity between PLC-γ1 and PLC-γ2, or between the five PTKs. © 1993 Academic Press, Inc.

引用

收藏

页码：1028 / 1033

页数：6

相关论文

共 37 条

[1] STIMULATION OF FC-GAMMA-RIIIA RESULTS IN PHOSPHOLIPASE C-GAMMA-1 TYROSINE PHOSPHORYLATION AND P56(LCK) ACTIVATION [J].

AZZONI, L ;

KAMOUN, M ;

SALCEDO, TW ;

KANAKARAJ, P ;

PERUSSIA, B .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 176 (06) :1745-1750

[2] INOSITOL TRISPHOSPHATE, A NOVEL 2ND MESSENGER IN CELLULAR SIGNAL TRANSDUCTION [J].

BERRIDGE, MJ ;

IRVINE, RF .

NATURE, 1984, 312 (5992) :315-321

[3]

BOLEN JB, 1991, ADV CANCER RES, V57, P103

[4] ANTIIMMUNOGLOBULIN STIMULATION OF LYMPHOCYTES-B ACTIVATES SRC-RELATED PROTEIN-TYROSINE KINASES [J].

BURKHARDT, AL ;

BRUNSWICK, M ;

BOLEN, JB ;

MOND, JJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (16) :7410-7414

[5] ASSOCIATION BETWEEN LYMPHOCYTE-B MEMBRANE IMMUNOGLOBULIN AND MULTIPLE MEMBERS OF THE SRC FAMILY OF PROTEIN TYROSINE KINASES [J].

CAMPBELL, MA ;

SEFTON, BM .

MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (05) :2315-2321

[6] TYROSINE PHOSPHORYLATION OF PHOSPHOLIPASE-C INDUCED BY MEMBRANE IMMUNOGLOBULIN IN LYMPHOCYTES-B [J].

CARTER, RH ;

PARK, DJ ;

RHEE, SG ;

FEARON, DT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (07) :2745-2749

[7] PREDOMINANT EXPRESSION AND ACTIVATION-INDUCED TYROSINE PHOSPHORYLATION OF PHOSPHOLIPASE C-GAMMA-2 IN LYMPHOCYTES-B [J].

COGGESHALL, KM ;

MCHUGH, JC ;

ALTMAN, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (12) :5660-5664

[8] PHOSPHOLIPASE C-GAMMA A SUBSTRATE FOR PDGF RECEPTOR KINASE, IS NOT PHOSPHORYLATED ON TYROSINE DURING THE MITOGENIC RESPONSE TO CSF-1 [J].

DOWNING, JR ;

MARGOLIS, BL ;

ZILBERSTEIN, A ;

ASHMUN, RA ;

ULLRICH, A ;

SHERR, CJ ;

SCHLESSINGER, J .

EMBO JOURNAL, 1989, 8 (11) :3345-3350

[9]

EISEMAN E, 1990, CANCER CELL-MON REV, V2, P303

[10]

EISEMAN E, 1992, NATURE, V355, P78

← 1 2 3 4 →