SEROLOGIC EVIDENCE FOR HUMAN EHRLICHIOSIS IN AFRICA

被引:22
作者
BROUQUI, P [1 ]
LECAM, C [1 ]
KELLY, PJ [1 ]
LAURENS, R [1 ]
TOUNKARA, A [1 ]
SAWADOGO, S [1 ]
VELOMARCEL [1 ]
GONDAO, L [1 ]
FAUGERE, B [1 ]
DELMONT, J [1 ]
BOURGEADE, A [1 ]
RAOULT, D [1 ]
机构
[1] FAC MED TIMONE,UNITE RICKETTSIES,F-13385 MARSEILLE 5,FRANCE
关键词
AFRICA; EPIDEMIOLOGY; EHRLICHIA CHAFFEENSIS; HUMAN EHRLICHIOSIS; SEROPREVALENCE; WESTERN IMMUNOBLOT;
D O I
10.1007/BF01719283
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Human ehrlichiosis is a recently recognized rickettsial disease. It is caused by Ehrlichia chaffeensis, an intraleucocytic Gram-negative, obligate intracellular bacterium, grouped within the genus Ehrlichiae. Most human cases of ehrlichiosis have been diagnosed in the USA. Two cases have been reported outside of the USA, one in Europe and one in Africa. From 1 January to 30 June 1992, 765 sera from blood donors or other asymptomatic subjects in 8 African countries, including Ivory Coast, Burkina Faso, Mall, Central African Republic, Angola, Zimbabwe, Mozambique and Commores Islands, were tested by indirect immunofluorescence for the presence of E. chaffeensis antibodies. Positive sera were confirmed by Western immunoblotting. Only two of 765 sera tested were positive. One serum obtained from Burkina Faso had an IgG titer of 1:200 and one from Mozambique had an IgG titer of 1:80. Human ehrlichiosis seems to occur infrequently in Africa, although many more sera from additional African countries need to be evaluated.
引用
收藏
页码:695 / 698
页数:4
相关论文
共 20 条
[1]  
Dawson J.E., Anderson B.E., Fishbein D.B., Et al., Isolation and characterization of an Ehrlichia from a patient diagnosed with human ehrlichiosis, J Clin Microbiol, 29, pp. 2741-2745, (1991)
[2]  
Rikihisa Y., The tribe Ehrlichiae and ehrlichial diseases, Clin Microbiol Rev, 4, pp. 286-308, (1991)
[3]  
Maeda K., Markowitz N., Hawley R.C., Ristic M., Cox D., McDade J., Human infection with Ehrlichia canis, a leukocytic rickettsia, N Engl J Med, 316, pp. 853-856, (1987)
[4]  
Morais J.D., Dawson J.E., Greene C., Filipe A.R., Galhardas L.C., Bacellar F., First European case of ehrlichiosis, Lancet, 338, pp. 633-634, (1991)
[5]  
Uhaa I.J., Maclean J.D., Greene C.R., Fishbein D.B., A case of human ehrlichiosis aquired in Mali: Clinical and laboratory findings, Am J Trop Med Hyg, 46, pp. 161-164, (1992)
[6]  
Dunn B.E., Monson T.P., Dumler J.S., Et al., Identification of Ehrlichia chaffeensis morulae in cerebrospinal fluid mononuclear cells, J Clin Microbiol, 30, pp. 2207-2210, (1992)
[7]  
Dumler J.S., Walker D.H., Human ehrlichiosis, Current Opinion in Infectious Disease, 4, pp. 597-602, (1991)
[8]  
Dumler J.S., Brouqui P., Aronson J., Taylor J.P., Walker D.H., Identification of Ehrlichia in human tissue, N Engl J Med, 325, pp. 1109-1110, (1991)
[9]  
Wellman M.I., Krakowka S., Jacobs R.M., Kociba G.J., A macrophage-monocyte cell line from a dog with malignant histiocytosis, In Vitro Cell Dev Biol, 24, pp. 223-229, (1988)
[10]  
Brouqui P., Raoult D., Vidor E., Lack of co-transmission of Rickettsia conorii and Ehrlichia canis in human beings in the south of France, Eur J Epidemiol, 5, pp. 110-112, (1989)