NEURAL CELL-ADHESION MOLECULE (NCAM) AS A QUANTITATIVE MARKER IN SYNAPTIC REMODELING

被引：55

作者：

JORGENSEN, OS ^{[1
]}

机构：

[1] UNIV COPENHAGEN,DEPT PHARMACOL,NEUROPSYCHIAT LAB,COPENHAGEN,DENMARK

来源：

NEUROCHEMICAL RESEARCH | 1995年 / 20卷 / 05期

关键词：

NEURAL CELL ADHESION MOLECULE; NCAM; D3; SNAP-25; SYNAPTIC REMODELING; REVIEW; QUANTIFICATION; IMMUNOELECTROPHORESIS;

D O I：

10.1007/BF01694535

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The neural cell adhesion molecule (NCAM) participates in adhesion and neuritic outgrowth during nervous system development. In the adult brain, NCAM is considered to be involved in neuronal sprouting and synaptic remodeling. The NCAM concentration of brain tissue has proved to be a useful marker of these processes, especially when viewed in comparison with the concentration of a marker of mature synapses, e.g. D3-protein (SNAP-25) or synaptophysin. The present review focusses on studies of adult brain in which NCAM concentration estimates and NCAM/D3 ratios have been used to evaluate the rate of synaptic remodeling in brain damage and degenerative diseases.

引用

页码：533 / 547

页数：15

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