AN OVERVIEW OF PAROXETINE IN THE ELDERLY

被引:16
作者
DUNNER, DL [1 ]
机构
[1] UNIV WASHINGTON,DEPT PSYCHIAT & BEHAV SCI,SEATTLE,WA 98195
关键词
PAROXETINE; DEPRESSION; ELDERLY;
D O I
10.1159/000213617
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Depression in the elderly is an increasingly prevalent problem affecting some 15% of the elderly population and can be difficult to diagnose and treat. Complicating factors include poor compliance, the high frequency of concomitant disease, and the alterations in drug absorption and metabolism with age. This paper reviews controlled studies of the treatment of depression in elderly patients using paroxetine, a selective serotonin reuptake inhibitor. The studies demonstrate that paroxetine has efficacy in these patients which is similar to that of comparative compounds. The side effect profile of paroxetine is favourable, as compared with tricyclics, in terms of cardiovascular effects. The side effects of paroxetine in the elderly are similar to those reported in younger individuals. The improved tolerability profile of paroxetine is particularly welcome for the treatment of the elderly who have an increased sensitivity to adverse effects of drug therapy.
引用
收藏
页码:21 / 27
页数:7
相关论文
共 31 条
[1]   THE PHARMACOKINETICS OF PAROXETINE IN THE ELDERLY [J].
BAYER, AJ ;
ROBERTS, NA ;
ALLEN, EA ;
HORAN, M ;
ROUTLEDGE, PA ;
SWIFT, CG ;
BYRNE, MM ;
CLARKSON, A ;
ZUSSMAN, BD .
ACTA PSYCHIATRICA SCANDINAVICA, 1989, 80 :85-86
[2]  
BOYER WF, 1991, PERSPECT PSYCHIATR C, V1, P81
[3]  
CARNEY MWP, 1986, ASSESSMENT DEPRESSIO, P201
[4]  
COHN CK, 1990, J CLIN PSYCHIAT, V51, P28
[5]  
DORMAN R, 1990, 17TH CINP C KYOT
[6]  
DUNNER DL, 1992, ADV THER, V9, P350
[7]  
DUNNER DL, 1992, J CLIN PSYCHIAT, V53, P21
[8]  
DUNNER DL, 1992, J CLIN PSYCHIAT, V53, P57
[9]  
FEIGHNER JP, 1985, J CLIN PSYCHIAT, V46, P20
[10]   DIAGNOSTIC CRITERIA FOR USE IN PSYCHIATRIC RESEARCH [J].
FEIGHNER, JP ;
WOODRUFF, RA ;
WINOKUR, G ;
MUNOZ, R ;
ROBINS, E ;
GUZE, SB .
ARCHIVES OF GENERAL PSYCHIATRY, 1972, 26 (01) :57-&