IN-VIVO CYTOTOXIC T-LYMPHOCYTE INDUCTION MAY TAKE PLACE VIA CD8(+) T-HELPER LYMPHOCYTES

被引：11

作者：

LASARTE, JJ ^{[1
]}

SAROBE, P ^{[1
]}

PRIETO, J ^{[1
]}

BORRASCUESTA, F ^{[1
]}

机构：

[1] UNIV NAVARRA, FAC MED, DEPT MED INTERNA, E-31080 PAMPLONA, SPAIN

来源：

RESEARCH IN IMMUNOLOGY | 1995年 / 146卷 / 01期

关键词：

HIV; T LYMPHOCYTE; AIDS; IL2; CYTOTOXICITY; INDUCTION; CD8(+); T HELPER CELLS; DETERMINANTS; HIV-1; GP120; V3; DOMAIN; PEPTIDE CONSTRUCT; MOUSE; MHC; APC; CTL; CANCER THERAPY; VACCINE DESIGN;

D O I：

10.1016/0923-2494(96)80238-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunization of mice with peptide constructs, consisting of a determinant recognized by T cytotoxic cells colinearly linked to a determinant recognized by T helper cells (TDc-TDh) was able to induce cytotoxic T lymphocytes in vivo. Interestingly, this induction could be achieved in the absence of adjuvant in non-depleted as well as in CD4(+)-cell-depleted BALB/c mice. In the latter case, induction took place simultaneously with the activation of CD8(+) T helper cells specific for a TDh contained within the RIQRGPGRAFVTIGK from the immunodominant V3 loop of HIV1 gp120. The possible implications of these findings in HIV infection and AIDS disease are discussed.

引用

页码：35 / 44

页数：10

共 42 条

[1] T4+ T-HELPER CELL-FUNCTION INVIVO - DIFFERENTIAL REQUIREMENT FOR INDUCTION OF ANTIVIRAL CYTO-TOXIC T-CELL AND ANTIBODY-RESPONSES [J].

AHMED, R ;

BUTLER, LD ;

BHATTI, L .

JOURNAL OF VIROLOGY, 1988, 62 (06) :2102-2106

[2] ANTIVIRAL CYTOTOXIC T-CELL RESPONSE INDUCED BY INVIVO PRIMING WITH A FREE SYNTHETIC PEPTIDE [J].

AICHELE, P ;

HENGARTNER, H ;

ZINKERNAGEL, RM ;

SCHULZ, M .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 171 (05) :1815-1820

[3]

ALLAN W, 1990, J IMMUNOL, V144, P3980

[4]

Atherton E, 1989, J CHEM SOC P1, V1, P538

[5] CYTO-TOXIC T-CELL RESPONSE TO RESPIRATORY SYNCYTIAL VIRUS IN MICE [J].

BANGHAM, CRM ;

CANNON, MJ ;

KARZON, DT ;

ASKONAS, BA .

JOURNAL OF VIROLOGY, 1985, 56 (01) :55-59

[6] DEVELOPMENT OF ARTIFICIAL VACCINES AGAINST HIV USING DEFINED EPITOPES [J].

BERZOFSKY, JA .

FASEB JOURNAL, 1991, 5 (10) :2412-2418

[7] INDUCTION OF CYTOTOXIC T-CELL RESPONSES INVIVO IN THE ABSENCE OF CD4 HELPER-CELLS [J].

BULLER, RML ;

HOLMES, KL ;

HUGIN, A ;

FREDERICKSON, TN ;

MORSE, HC .

NATURE, 1987, 328 (6125) :77-79

[8] INDUCTION OF OVALBUMIN-SPECIFIC CYTO-TOXIC T-CELLS BY INVIVO PEPTIDE IMMUNIZATION [J].

CARBONE, FR ;

BEVAN, MJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 169 (03) :603-612

[9] T-CELL CLONES SPECIFIC FOR AN AMPHIPATHIC ALPHA-HELICAL REGION OF SPERM WHALE MYOGLOBIN SHOW DIFFERING FINE SPECIFICITIES FOR SYNTHETIC PEPTIDES - A MULTIVIEW SINGLE STRUCTURE INTERPRETATION OF IMMUNODOMINANCE [J].

CEASE, KB ;

BERKOWER, I ;

YORKJOLLEY, J ;

BERZOFSKY, JA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1986, 164 (05) :1779-1784

[10] HELPER T-CELL ANTIGENIC SITE IDENTIFICATION IN THE ACQUIRED-IMMUNODEFICIENCY-SYNDROME VIRUS GP120 ENVELOPE PROTEIN AND INDUCTION OF IMMUNITY IN MICE TO THE NATIVE PROTEIN USING A 16-RESIDUE SYNTHETIC PEPTIDE [J].

CEASE, KB ;

MARGALIT, H ;

CORNETTE, JL ;

PUTNEY, SD ;

ROBEY, WG ;

OUYANG, C ;

STREICHER, HZ ;

FISCHINGER, PJ ;

GALLO, RC ;

DELISI, C ;

BERZOFSKY, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (12) :4249-4253

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