WHOLE EMBRYO CULTURE AND TERATOGENESIS

被引：11

作者：

STEELE, CE

机构：

[1] Boots Pharmaceuticals Research Department, Nottingham

来源：

HUMAN REPRODUCTION | 1991年 / 6卷 / 01期

关键词：

TERATOGENESIS; EMBRYO CULTURE; RETINOIDS;

D O I：

10.1093/oxfordjournals.humrep.a137249

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Whole embryo culture (WEC) is under evaluation in numerous laboratories to determine the role it should play in teratogen testing. There is general agreement that its role is to complement the Segment II Teratology studies required by regulatory authorities. Currently it is used as a 'screen' in order to minimize the number of compounds used in animal tests and also to determine the mechanism(s) of teratogenesis. This brief review focuses on the study of retinoid teratogenicity in WEC in order to illustrate these points.

引用

页码：144 / 147

页数：4

共 29 条

[1]

Bechter R., Taccard G., Medium and tissue levels of Acyclovir and Etretinate in the rat whole embryo culture system, Pharmacokinetics in Teratogenesis, 2, (1987)

[2]

Beck F., Huxham I.M., Gulamhasein A.P., Mechanisms of Alcohol Damage in Utero.Pitman, (1984)

[3]

Beck F., Mensah-Brown E., Pratten M.K., Development of a method for assessing the acute toxicity of chemicals on early postimplantation embryos, Arch. Toxicol, 11, pp. 155-158, (1987)

[4]

Brown N.A., Teratogenicity of carboxylic acids: Distribution studies in whole embryo culture, Pharmacokinetics in Teratogenesis, 2, (1987)

[5]

Brown N.A., Fabro S., Quantitation of rat embryonic development in vitro: A morphological scoring system, Teratology, 24, pp. 65-78, (1981)

[6]

Cockroft D.L., New D.A.T., Abnormalities induced in cultured rat embryos by hyperthermia, Teratology, 17, pp. 277-284, (1978)

[7]

Cockroft D.L., Steele C.E., Postimplantation embryo culture and its application to problems in teratology, Vitro Methods in Toxicology, (1987)

[8]

Eto K., Figueroa A., Tamura G., Pratt R.M., Induction of cleft lip in cultured rat embryos by localized administration of tunicamycin, J. Embryol. Exp. Morphol., 64, pp. 1-9, (1981)

[9]

Fantel A.G., Greenaway J.C., Juchau M.R., Shepard T.H., Teratogenic bioactivation of cyclophosphamide in vitro, Life Sci., 25, pp. 67-72, (1979)

[10]

Flint O.P., An in vitro test for teratogens using cultures of rat embryo cells, Vitro Methods in Toxicology, (1987)

← 1 2 3 →