SYNTHESIS OF ANALOGS OF 5-IODO-2'-DEOXYURIDINE-5'-DIPHOSPHATE

被引：32

作者：

JENNINGS, LJ ^{[1
]}

MACCHIA, M ^{[1
]}

PARKIN, A ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT, YEW TREE BOTTOM RD, EPSOM KT18 5XQ, SURREY, ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1992年 / 17期

关键词：

D O I：

10.1039/p19920002197

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of three types of diphosphate analogues of 5-iodo-2'-deoxyuridine-5'-diphosphate is reported. Routes are described to the 5'-phosphonoacetamido, the 5'-N-phosphonosulfamoyl and the 5'-O-sulfamoylcarbamoyl derivatives, 2, 3 and 4 starting from 5-iodo-2'-deoxyuridine (IDU). In the course of the synthesis of 3, the 5'-sulfamoyl derivative 19, an analogue of IDU 5'-monophosphate was prepared. The antiherpes virus activity of 2, 4 and 19 is reported.

引用

页码：2197 / 2202

页数：6

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