MECHANISM OF NEOCARZINOSTATIN ACTION - ROLE OF DNA MICROSTRUCTURE IN DETERMINATION OF CHEMISTRY OF BISTRANDED OXIDATIVE DAMAGE

被引:358
作者
GOLDBERG, IH
机构
[1] Department of Biological Chemistry, Department of Molecular Pharmacology, Harvard Medical School, Boston
关键词
NON-PROTEIN CHROMOPHORE; ANTITUMOR ANTIBIOTIC NEOCARZINOSTATIN; DEOXYRIBONUCLEIC-ACID; SUGAR DAMAGE; STRAND SCISSION; BASE RELEASE; NAPHTHALENECARBOXYLIC ACID; MEDIATED DEGRADATION; SECONDARY STRUCTURE; SODIUM-BOROHYDRIDE;
D O I
10.1021/ar00007a001
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
[No abstract available]
引用
收藏
页码:191 / 198
页数:8
相关论文
共 87 条
  • [1] PROTON NMR-STUDIES OF APO-NEOCARZINOSTATIN FROM STREPTOMYCES-CARZINOSTATICUS - SEQUENCE-SPECIFIC ASSIGNMENT AND SECONDARY STRUCTURE
    ADJADJ, E
    MISPELTER, J
    QUINIOU, E
    DIMICOLI, JL
    FAVAUDON, V
    LHOSTE, JM
    [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1990, 190 (02): : 263 - 271
  • [2] NEOCARZINOSTATIN - CHEMICAL CHARACTERIZATION AND PARTIAL STRUCTURE OF THE NON-PROTEIN CHROMOPHORE
    ALBERSSCHONBERG, G
    DEWEY, RS
    HENSENS, OD
    LIESCH, JM
    NAPIER, MA
    GOLDBERG, IH
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1980, 95 (03) : 1351 - 1356
  • [3] DNA STRAND SCISSION BY ANTITUMOR PROTEIN NEOCARZINOSTATIN
    BEERMAN, TA
    GOLDBERG, IH
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1974, 59 (04) : 1254 - 1261
  • [4] REACTIVE 1,4-DEHYDROAROMATICS
    BERGMAN, RG
    [J]. ACCOUNTS OF CHEMICAL RESEARCH, 1973, 6 (01) : 25 - 31
  • [5] NEOCARZINOSTATIN ABSTRACTS A HYDROGEN DURING FORMATION OF NUCLEOTIDE-5'-ALDEHYDE ON DNA
    CHARNAS, RL
    GOLDBERG, IH
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 122 (02) : 642 - 648
  • [6] GENERATION OF SUPEROXIDE FREE-RADICAL BY NEOCARZINOSTATIN AND ITS POSSIBLE ROLE IN DNA DAMAGE
    CHIN, DH
    GOLDBERG, IH
    [J]. BIOCHEMISTRY, 1986, 25 (05) : 1009 - 1015
  • [7] SITES IN THE DIYNE ENE BICYCLIC CORE OF NEOCARZINOSTATIN CHROMOPHORE RESPONSIBLE FOR HYDROGEN ABSTRACTION FROM DNA
    CHIN, DH
    ZENG, CH
    COSTELLO, CE
    GOLDBERG, IH
    [J]. BIOCHEMISTRY, 1988, 27 (21) : 8106 - 8114
  • [8] 3'-FORMYL PHOSPHATE-ENDED DNA - HIGH-ENERGY INTERMEDIATE IN ANTIBIOTIC-INDUCED DNA SUGAR DAMAGE
    CHIN, DH
    KAPPEN, LS
    GOLDBERG, IH
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (20) : 7070 - 7074
  • [9] CHIN DH, 1984, J BIOL CHEM, V259, P9975
  • [10] MODE OF REVERSIBLE BINDING OF NEOCARZINOSTATIN CHROMOPHORE TO DNA - EVIDENCE FOR BINDING VIA THE MINOR GROOVE
    DASGUPTA, D
    GOLDBERG, IH
    [J]. BIOCHEMISTRY, 1985, 24 (24) : 6913 - 6920