CHILDHOOD BRAIN-TUMOR - PRESENTATION AT YOUNGER AGE IS ASSOCIATED WITH A FAMILY TUMOR HISTORY

被引：13

作者：

SUSSMAN, A ^{[1
]}

LEVITON, A ^{[1
]}

ALLRED, EN ^{[1
]}

ASCHENBRENER, C ^{[1
]}

AUSTIN, DF ^{[1
]}

GILLES, FH ^{[1
]}

HEDLEYWHYTE, ET ^{[1
]}

KOLONEL, LN ^{[1
]}

LYON, JL ^{[1
]}

SWANSON, GM ^{[1
]}

WEST, D ^{[1
]}

机构：

[1] CHILDRENS HOSP MED CTR,GARDNER 612,300 LONGWOOD AVE,BOSTON,MA 02115

来源：

CANCER CAUSES & CONTROL | 1990年 / 1卷 / 01期

关键词：

BRAIN; NEOPLASMS; CHILD; THEORETICAL MODELS;

D O I：

10.1007/BF00053186

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In registry-based sample of 361 children with a brain tumor, those whose grandparents and great-grandparents had a history of any kind of tumor were younger at the time of presentation than were those who lacked this family history (p = 0.1). In post hoc analyses, the age difference was most apparent among children with cerebral tumors, and when family history was limited to brain tumors and to great-grandparents. These findings are in keeping with the hypothesis that a familial tumor diathesis contributes to an early age at onset of a brain tumor in some children.

引用

页码：75 / 79

页数：5

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