PREVALENCE IN CRYPTOCOCCUS-NEOFORMANS STRAINS OF A POLYSACCHARIDE EPITOPE WHICH CAN ELICIT PROTECTIVE ANTIBODIES

被引：14

作者：

CLEARE, W

MUKHERJEE, S

SPITZER, ED

CASADEVALL, A

机构：

[1] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT MED,DIV INFECT DIS,1300 MORRIS PK AVE,BRONX,NY 10461

[2] SUNY STONY BROOK,DEPT PATHOL,STONY BROOK,NY 11794

[3] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT MICROBIOL & IMMUNOL,BRONX,NY 10461

来源：

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY | 1994年 / 1卷 / 06期

关键词：

D O I：

10.1128/CDLI.1.6.737-740.1994

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Monoclonal antibody (MAb) 2H1 binds to an epitope in the capsule of Cryptococcus neoformans that can elicit protective antibodies. The binding of MAb 2H1 to C. neoformans strains was studied by agglutination, immunofluorescence, and phagocytosis assays. The MAb 2H1 epitope was present in all 21 isolates studied, including those recovered from patients with recurrent infections.

引用

收藏

页码：737 / 740

页数：4

相关论文

共 30 条

[1] POORLY ENCAPSULATED CRYPTOCOCCUS-NEOFORMANS FROM PATIENTS WITH AIDS .1. PRELIMINARY-OBSERVATIONS [J].

BOTTONE, EJ ;

TOMA, M ;

JOHANSSON, BE ;

WORMSER, GP .

AIDS RESEARCH, 1986, 2 (03) :211-218

[2]

BOTTONE EJ, 1984, LANCET, V2, P553

[3] EXTENSIVE ALLELIC VARIATION IN CRYPTOCOCCUS-NEOFORMANS [J].

CASADEVALL, A ;

FREUNDLICH, LF ;

MARSH, L ;

SCHARFF, MD .

JOURNAL OF CLINICAL MICROBIOLOGY, 1992, 30 (05) :1080-1084

[4] SUSCEPTIBILITIES OF SERIAL CRYPTOCOCCUS-NEOFORMANS ISOLATES FROM PATIENTS WITH RECURRENT CRYPTOCOCCAL MENINGITIS TO AMPHOTERICIN-B AND FLUCONAZOLE [J].

CASADEVALL, A ;

SPITZER, ED ;

WEBB, D ;

RINALDI, MG .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (06) :1383-1386

[5] MONOCLONAL-ANTIBODY BASED ELISAS FOR CRYPTOCOCCAL POLYSACCHARIDE [J].

CASADEVALL, A ;

MUKHERJEE, J ;

SCHARFF, MD .

JOURNAL OF IMMUNOLOGICAL METHODS, 1992, 154 (01) :27-35

[6]

CASADEVALL A, 1992, J INFECT DIS, V65, P1086

[7] KILLING OF VIRULENT MYCOBACTERIUM-TUBERCULOSIS BY REACTIVE NITROGEN INTERMEDIATES PRODUCED BY ACTIVATED MURINE MACROPHAGES [J].

CHAN, J ;

XING, Y ;

MAGLIOZZO, RS ;

BLOOM, BR .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 175 (04) :1111-1122

[8] FACILITATED ISOLATION, PURIFICATION, AND ANALYSIS OF GLUCURONOXYLOMANNAN OF CRYPTOCOCCUS-NEOFORMANS [J].

CHERNIAK, R ;

MORRIS, LC ;

ANDERSON, BC ;

MEYER, SA .

INFECTION AND IMMUNITY, 1991, 59 (01) :59-64

[9] INFECTIONS WITH CRYPTOCOCCUS-NEOFORMANS IN THE ACQUIRED IMMUNODEFICIENCY SYNDROME [J].

CHUCK, SL ;

SANDE, MA .

NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (12) :794-799

[10] RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISM ANALYSIS OF CRYPTOCOCCUS-NEOFORMANS ISOLATES FROM ENVIRONMENTAL (PIGEON EXCRETA) AND CLINICAL SOURCES IN NEW-YORK-CITY [J].

CURRIE, BP ;

FREUNDLICH, LF ;

CASADEVALL, A .

JOURNAL OF CLINICAL MICROBIOLOGY, 1994, 32 (05) :1188-1192