MEDIATORS OF JOINT SWELLING AND DAMAGE IN RHEUMATOID-ARTHRITIS AND PRISTANE INDUCED ARTHRITIS

被引：8

作者：

ELSON, CJ

THOMPSON, SJ

WESTACOTT, CI

BHOOLA, KD

机构：

[1] Department of Pathology and Microbiology and Pharmacology, School of Medical Sciences, University of Bristol, Bristol

来源：

AUTOIMMUNITY | 1992年 / 13卷 / 04期

关键词：

D O I：

10.3109/08916939209112342

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Joint swelling and tenderness in rheumatoid arthritis (RA) probably result from IgG aggregates activating complement with the consequent attraction of polymorphonuclear leucocytes (PMNs) and the liberation of their granule enzymes such as kininogenases. By contrast IL-1 and TNF are the major stimulants of cartilage and bone loss although other agents contribute. The fundamental drive for the production of these mediators is unknown but a role for heat shock proteins is suggested from work on pristane induced arthritis.

引用

页码：327 / 331

页数：5

共 47 条

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