NEUROTOXICITY OF IMMUNOTOXINS

被引：4

作者：

ILERCIL, O ^{[1
]}

LASKE, DW ^{[1
]}

WALBRIDGE, S ^{[1
]}

MUASZKO, K ^{[1
]}

OLDFIELD, EH ^{[1
]}

YOULE, RJ ^{[1
]}

机构：

[1] NINCDS,SURG NEUROL BRANCH,BIOCHEM SECT,BLDG 10,ROOM 5D37,BETHESDA,MD 20892

来源：

MOLECULAR AND CHEMICAL NEUROPATHOLOGY | 1994年 / 21卷 / 2-3期

关键词：

NEUROTOXICITY; IMMUNOTOXINS; MONOCLONAL ANTIBODIES; RICIN-A; MELANOMA; LYMPHOMA; LEUKEMIA; BREAST CARCINOMA; PERIPHERAL NERVE; SURAL NERVE; NEUROPATHY; SUBARACHNOID SPACE; LEPTOMENINGEAL NEOPLASIA; CEREBROSPINAL FLUID; PURKINJE CELLS; INTRAHECAL ADMINISTRATION;

D O I：

10.1007/BF02815363

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Immunotoxins are being tested for the therapy of systemic cancer and brain tumors. Neurotoxicity has been dose limiting for several of these antibody conjugates given systemically. We review the animal and clinical data related to the neurotoxicity of immunotoxins in attempt to understand the molecular basis for the unexpected neural involvement and to prevent or minimize this toxicity in future clinical trials.

引用

页码：379 / 386

页数：8

共 23 条

[1]

Adams R.D, 1989, PRINCIPLES NEUROLOGY

[2]

BOOKMAN MA, 1990, 2ND INT S IMM LAK BU

[3] SELECTIVE EXTRACTION OF SMALL AND LARGE MOLECULES FROM THE CEREBROSPINAL-FLUID BY PURKINJE NEURONS [J].

BORGES, LF ;

ELLIOTT, PJ ;

GILL, R ;

IVERSEN, SD ;

IVERSEN, LL .

SCIENCE, 1985, 228 (4697) :346-348

[4] TARGETED TOXIN THERAPY FOR THE TREATMENT OF CANCER [J].

FITZGERALD, D ;

PASTAN, I .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1989, 81 (19) :1455-1463

[5] PHASE-I STUDY OF AN ANTI-BREAST CANCER IMMUNOTOXIN BY CONTINUOUS INFUSION - REPORT OF A TARGETED TOXIC EFFECT NOT PREDICTED BY ANIMAL STUDIES [J].

GOULD, BJ ;

BOROWITZ, MJ ;

GROVES, ES ;

CARTER, PW ;

ANTHONY, D ;

WEINER, LM ;

FRANKEL, AE .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1989, 81 (10) :775-781

[6] HUMORAL IMMUNE-RESPONSE TO A RICIN-A CHAIN IMMUNOTOXIN IN PATIENTS WITH METASTATIC MELANOMA [J].

HERTLER, AA ;

SPITLER, LE ;

FRANKEL, AE .

CANCER DRUG DELIVERY, 1987, 4 (04) :245-253

[7]

HERTLER AA, 1988, J BIOL RESP MODIF, V7, P97

[8] IMPROVED TUMOR-SPECIFIC IMMUNOTOXINS IN THE TREATMENT OF CNS AND LEPTOMENINGEAL NEOPLASIA [J].

JOHNSON, VG ;

WROBEL, C ;

WILSON, D ;

ZOVICKIAN, J ;

GREENFIELD, L ;

OLDFIELD, EH ;

YOULE, R .

JOURNAL OF NEUROSURGERY, 1989, 70 (02) :240-248

[9]

LASHFORD LS, 1988, CANCER, V61, P857, DOI 10.1002/1097-0142(19880301)61:5<857::AID-CNCR2820610502>3.0.CO

[10]

2-S

← 1 2 3 →