THE FORMATION OF BENZO[A]PYRENE-DEOXYRIBONUCLEOSIDE ADDUCTS INVIVO AND INVITRO

被引：42

作者：

ASHURST, SW

COHEN, GM

机构：

[1] UNIV LONDON,SCH PHARM,DEPT PHARMACOL,TOXICOL UNIT,LONDON WC1N 1AX,ENGLAND

[2] UNIV SURREY,DEPT BIOCHEM,GUILDFORD GU2 5XH,SURREY,ENGLAND

来源：

CARCINOGENESIS | 1982年 / 3卷 / 03期

关键词：

D O I：

10.1093/carcin/3.3.267

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：267 / 273

页数：7

共 41 条

[1] BENZO[A]PYRENE-7,8-DIHYDRODIOL-9,10-EPOXIDE IS THE MAJOR METABOLITE INVOLVED IN THE BINDING OF BENZO[A]PYRENE TO DNA IN ISOLATED VIABLE RAT HEPATOCYTES [J].

ASHURST, SW ;

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CHEMICO-BIOLOGICAL INTERACTIONS, 1980, 29 (01) :117-127

[2] INVIVO FORMATION OF BENZO(A)PYRENE DIOL EPOXIDE-DEOXYADENOSINE ADDUCTS IN THE SKIN OF MICE SUSCEPTIBLE TO BENZO(A)PYRENE-INDUCED CARCINOGENESIS [J].

ASHURST, SW ;

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INTERNATIONAL JOURNAL OF CANCER, 1981, 27 (03) :357-364

[3] MAGNESIUM-IONS AFFECT THE QUANTITATIVE BUT NOT THE QUALITATIVE MICROSOME MEDIATED BINDING OF BENZO[A]-PYRENE TO DNA [J].

ASHURST, SW ;

COHEN, GM .

CHEMICO-BIOLOGICAL INTERACTIONS, 1979, 28 (2-3) :279-289

[4] METABOLISM OF BENZO[A]PYRENE BY CULTURED TRACHEO-BRONCHIAL TISSUES FROM MICE, RATS, HAMSTERS, BOVINES AND HUMANS [J].

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[5]

BAIRD W M, 1973, Cancer Research, V33, P2378

[6]

BAIRD WM, 1977, BIOCHEM BIOPH RES CO, V77, P162, DOI 10.1016/S0006-291X(77)80178-2

[7] LIMITATIONS OF METABOLIC-ACTIVATION SYSTEMS USED WITH INVITRO TESTS FOR CARCINOGENS [J].

BIGGER, CAH ;

TOMASZEWSKI, JE ;

DIPPLE, A ;

LAKE, RS .

SCIENCE, 1980, 209 (4455) :503-505

[8] BINDING TO MOUSE SKIN DNA OF BENZO[A]PYRENE, ITS 7,8-DIOL AND 7,8-DIOL-9,10-EPOXIDES IN RELATION TO THE TUMORIGENICITY OF THESE COMPOUNDS [J].

BROOKES, P .

CANCER LETTERS, 1979, 6 (4-5) :285-289

[9] TUMORIGENICITY OF OPTICAL ENANTIOMERS OF DIASTEREOMERIC BENZO[A]PYRENE 7,8-DIOL-9,10-EPOXIDES IN NEWBORN MICE - EXCEPTIONAL ACTIVITY OF(+)-7-BETA, 8-ALPHA-DIHYDROXY-9-ALPHA, 10-ALPHA-EPOXY-7,8.9.10-TETRAHYDROBENZOL[A]PYRENE [J].

BUENING, MK ;

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CONNEY, AH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (11) :5358-5361

[10] METABOLISM OF POLYCYCLIC-HYDROCARBONS AND ITS RELATIONSHIP TO CANCER [J].

DEPIERRE, JW ;

ERNSTER, L .

BIOCHIMICA ET BIOPHYSICA ACTA, 1978, 473 (3-4) :149-186

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