ANALYTICAL INFRARED SPECTRAL DIFFERENCES BETWEEN HUMAN NORMAL AND LEUKEMIC-CELLS (CLL) .1.

Two series of normal and leukemic lymphocytes were examined by infrared spectroscopy to try to find spectral differences connected with chemical and biological modifications. The bands at 965 and 530 cm-1, present only in the spectra of leukemic lymphocytes, assume particular significance. The C-H stretching region furnishes useful indications about the different ratios of the methyl groups, compared with the methylene ones in the 2 cases. The infrared bands characteristic of the leukemic lymphocytes seem to be due to chemical modifications not involving the DNA chain.