THE MATHEMATICAL BASIS OF MULTIVARIATE RISK SCREENING - WITH SPECIAL REFERENCE TO SCREENING FOR DOWNS-SYNDROME ASSOCIATED PREGNANCY

被引：104

作者：

REYNOLDS, TM

PENNEY, MD

机构：

[1] Clinical Chemistry Department, Royal Gwent Hospital, Newport, Gwent

来源：

ANNALS OF CLINICAL BIOCHEMISTRY | 1990年 / 27卷

关键词：

antenatal diagnosis; Gaussian distributions; matrix algebra; Trisomy; 21;

D O I：

10.1177/000456329002700506

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The underlying mathematical techniques behind the multivariate normal distribution are explained in principle and expanded in detail for up to three variables. The application of multivariate distributions to screening programs is described with particular reference to the calculation of risk ratios for the detection of Down's syndrome between 15 and 19 weeks of gestation. © 1990, Association for Clinical Biochemistry. All rights reserved.

引用

页码：452 / 458

页数：7

共 15 条

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