INVITRO EFFECTS OF CYCLOSPORINE ON GLOMERULAR FUNCTION

被引：13

作者：

WIEGMANN, TB ^{[1
]}

SHARMA, R ^{[1
]}

DIEDERICH, DA ^{[1
]}

SAVIN, VJ ^{[1
]}

机构：

[1] UNIV KANSAS,MED CTR,KIDNEY & UROL RES CTR,KANSAS CITY,KS 66103

来源：

AMERICAN JOURNAL OF THE MEDICAL SCIENCES | 1990年 / 299卷 / 03期

关键词：

cyclosporine; glomerular filtration rate; glomerular function; kidney; glomerulus;

D O I：

10.1097/00000441-199003000-00001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cyclosporine A (CsA) causes vasoconstriction and decrease in glomerular filtration rate. Experiments were conducted in isolated glomeruli to study effects of CsA of glomerular perfusion and independent of systemic or renal factors. CsA caused a dose dependent decrease in glomerular volume consistent with mesangial contraction. The ultrafiltration coefficient Kf was significantly lower after incubation in 4 x 10-4 M CsA when compared to control (2.81 ± 0.2 vs 5.19 ± 0.5 nl/min x Hg; p < 0.001). Hydraulic conductivity L(p) was diminished by CsA from 2.69 ± 0.11 to 1.41 ± 0.05 μl/min x mm Hg x cm2 (p < 0.001). These findings demonstrate a direct effect of CsA on the glomerulus which must be considered in addition to drug-induced changes in perfusion and tubular function.

引用

页码：149 / 152

页数：4

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