EFFECT OF A NEWLY SYNTHESIZED LEUKOTRIENE ANTAGONIST, (E)-2,2-DIETHYL-3'-2-2-(4-ISOPROPYL) THIAZOLYL ETHENYL SUCCINANILIC ACID (MCI-826), ON IMMUNOLOGICAL LIVER-INJURY AND NEPHRITIS IN MICE

被引：3

作者：

NAGAI, H

KITAGAKI, K

MIURA, T

SHIMAZAWA, T

KODA, A

机构：

[1] Department of Pharmacology, Gifu Pharmaceutical University, Gifu, 502, 5-6-1, Mitahorahigashi

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 1992年 / 47卷 / 01期

关键词：

D O I：

10.1016/0952-3278(92)90185-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of a newly synthesized leukotriene antagonist, (E)-2,2-diethyl-3'-2-2-(4-isopropyl) thiazolyl ethenyl succinanilic acid (MCI-826), on liver injury and nephritis in mice was studied. In order to confirm the anti-leukotriene activity of MCI-826, the effect of MCI-826 on leukotriene C4(LTC4)- and leukotriene D4(LTD4)-induced vasculitis, liver and kidney injury was studied. MCI-826 was found to clearly inhibit LTC4- and LTD4-induced vasculitis, as well as liver and kidney injury. In addition to LT-induced reactions, MCI-826 inhibited liver injury induced by injection of either an anti-basic liver protein antibody into DBA/2 mice that had been previously immunized with rabbit IgG or of a bacterial lipopolysaccharide (LPS) into Corynebacterium parvum pretreated DDY mice. Moreover, MCI-826 inhibited nephritis, caused by injecting antiglomerular basement membrane antibody into C57BL/6 mice. These results suggest that MCI-826 can be applied to the treatment of certain tissue inflammatory diseases.

引用

页码：51 / 57

页数：7

共 26 条

[1] THE EFFECT OF INHALED LEUKOTRIENE D4, HISTAMINE, OR ANTIGEN ON CENTRAL AND PERIPHERAL AIRWAYS OF GUINEA-PIGS - ANALYSIS OF BRONCHOGRAMS WITH AN INTERACTIVE IMAGE-ANALYSIS SYSTEM [J].