RESISTANCE-ASSOCIATED POINT MUTATIONS IN INSECTICIDE-INSENSITIVE ACETYLCHOLINESTERASE

被引：343

作者：

MUTERO, A ^{[1
]}

PRALAVORIO, M ^{[1
]}

BRIDE, JM ^{[1
]}

FOURNIER, D ^{[1
]}

机构：

[1] INRA,BIOL INVERTEBRES LAB,ANTIBES,FRANCE

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 13期

关键词：

D O I：

10.1073/pnas.91.13.5922

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Extensive utilization of pesticides against insects provides us with a good model for studying the adaptation of a eukaryotic genome to a strong selective pressure. One mechanism of resistance is the alteration of acetylcholinesterase (EC 3.1.1.7), the molecular target for organophosphates and carbamates. Here, we report the sequence analysis of the Ace gene in several resistant field strains of Drosophila melanogaster. This analysis resulted in the identification of five point mutations associated with reduced sensitivities to insecticides. In some cases, several of these mutations were found to be combined in the same protein, leading to different resistance patterns. Our results suggest that recombination between resistant alleles preexisting in natural populations is a mechanism by which insects rapidly adapt to new selective pressures.

引用

页码：5922 / 5926

页数：5

共 26 条

[1] SOME PROPERTIES OF SPECIFIC CHOLINESTERASE WITH PARTICULAR REFERENCE TO THE MECHANISM OF INHIBITION BY DIETHYL PARA-NITROPHENYL THIOPHOSPHATE (E 605) AND ANALOGUES [J].