SUPPRESSED PERIPHERAL AND PLACENTAL BLOOD LYMPHOPROLIFERATIVE RESPONSES IN 1ST PREGNANCIES - RELEVANCE TO MALARIA

被引:52
作者
RASHEED, FN
BULMER, JN
DUNN, DT
MENENDEZ, C
JAWLA, MFB
JEPSON, A
JAKOBSEN, PH
GREENWOOD, BM
机构
[1] UNIV NEWCASTLE UPON TYNE,ROYAL VICTORIA INFIRM,SCH PATHOL SCI,DIV PATHOL,NEWCASTLE TYNE NE1 4LP,TYNE & WEAR,ENGLAND
[2] MRC,FAJARA,SENEGAMBIA
[3] INST CHILD HLTH,DEPT PAEDIAT EPIDEMIOL,LONDON WC1N 1EH,ENGLAND
[4] HOSP CLIN BARCELONA,E-08036 BARCELONA,SPAIN
[5] MED & HLTH DEPT,BANJUL,SENEGAMBIA
[6] STATE UNIV HOSP COPENHAGEN,DEPT INFECT DIS M7722,MALARIA RES GRP,DK-2200 COPENHAGEN N,DENMARK
[7] UNIV COPENHAGEN,INST MED MICROBIOL,DK-1168 COPENHAGEN,DENMARK
关键词
D O I
10.4269/ajtmh.1993.48.154
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
An understanding of processes that predispose pregnant women, and in particular primigravidae, to malaria infection is essential to improve malaria management in pregnancy. Lymphoproliferative responses to malaria-specific (F32, 190L, and 190N) as well as other antigens (Candida and purified protein derivative [PPD]) were examined in the peripheral and placental blood of 102 Gambian women at the time of delivery. The lymphoproliferative responses of placental cells were poor to all antigens compared with those of peripheral blood (Candida P < 0.001, PPD P < 0.001, F32 P = 0.008, 190L P = 0.003, and 190N P = 0.10). Reduced proliferative capacity of placental mononuclear cells may contribute to heavy parasite colonization of this organ. Proliferation to malarial and PPD but not Candida antigens was selectively suppressed in peripheral and placental blood of primiparae relative to multiparae (F32 P = 0.07, 190L P = 0.09, 190N P = 0.007, PPD P = 0.09). Autologous plasma contained factors that suppressed lymphoproliferative responses to the same series of antigens to which the primiparae responded poorly (F32 P < 0.001, 190L P < 0.001, 190N P < 0.001, PPD P = 0.03). Malarial antibody levels were comparable among women of different parities and between peripheral and placental blood. Primigravidae may be more susceptible to malaria because of unique physiologic factors, such as higher levels of circulating immunosuppressive corticosteroids (P < 0.001), rather than differences in levels of acquired immunity.
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页码:154 / 160
页数:7
相关论文
共 18 条
[1]  
BLACKLOCK DB, 1925, ANN TROP MED PARASIT, V19, P37
[2]   SEQUESTRATION OF PLASMODIUM-FALCIPARUM INFECTED ERYTHROCYTES IN THE PLACENTA [J].
BRAY, RS ;
SINDEN, RE .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1979, 73 (06) :716-719
[3]  
BULMER JN, 1993, IN PRESS HISTOPATHOL
[4]  
BURKE CW, 1985, OXFORD TXB MED
[5]  
HUTTER NH, 1987, THESIS U LONDON LOND
[6]   DEMONSTRATION OF SOLUBLE PLASMODIUM-FALCIPARUM ANTIGENS REACTIVE WITH LIMULUS AMEBOCYTE LYSATE AND POLYMYXIN-B [J].
JAKOBSEN, PH ;
BAEK, L ;
JEPSEN, S .
PARASITE IMMUNOLOGY, 1988, 10 (06) :593-606
[7]  
MCGREGOR I, 1984, T ROY SOC TROP MED H, V78, P1, DOI 10.1016/0035-9203(84)90160-3
[8]   MALARIA INFECTION OF THE PLACENTA IN THE GAMBIA, WEST-AFRICA - ITS INCIDENCE AND RELATIONSHIP TO STILLBIRTH, BIRTH-WEIGHT AND PLACENTAL WEIGHT [J].
MCGREGOR, IA ;
WILSON, ME ;
BILLEWICZ, WZ .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1983, 77 (02) :232-244
[9]   EPIDEMIOLOGY, MALARIA AND PREGNANCY [J].
MCGREGOR, IA .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1984, 33 (04) :517-525
[10]   MALARIA DURING PREGNANCY IN AN AREA OF UNSTABLE ENDEMICITY [J].
NOSTEN, F ;
TERKUILE, F ;
MAELANKIRRI, L ;
DECLUDT, B ;
WHITE, NJ .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1991, 85 (04) :424-429