A GENE FROM CHROMOSOME-4P16.3 WITH SIMILARITY TO A SUPERFAMILY OF TRANSPORTER PROTEINS

被引：19

作者：

DUYAO, MP

TAYLOR, SAM

BUCKLER, AJ

AMBROSE, CM

LIN, C

GROOT, N

CHURCH, D

BARNES, G

WASMUTH, JJ

HOUSMAN, DE

MACDONALD, ME

GUSELLA, JF

机构：

[1] MASSACHUSETTS GEN HOSP, MOLEC NEUROGENET UNIT, BOSTON, MA 02114 USA

[2] MIT, CTR CANC RES, CAMBRIDGE, MA 02139 USA

[3] HARVARD UNIV, SCH MED, DEPT GENET, BOSTON, MA 02115 USA

[4] UNIV CALIF IRVINE, DEPT BIOL CHEM, IRVINE, CA 92717 USA

来源：

HUMAN MOLECULAR GENETICS | 1993年 / 2卷 / 06期

关键词：

D O I：

10.1093/hmg/2.6.673

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have previously used exon amplification to identify the ADD1 gene in cosmid Y24 from the Huntington's disease (HD) region of 4p16.3. The same technique has now yielded a second gene from this cosmid. This gene appears to encode a novel member of a superfamily of transporter proteins that includes active and passive transporters in a number of species. The predicted protein of 455 amino acids displays sequence similarity with the E.coli tetracycline resistance efflux protein encoded by cloning vector pBR322, and with a number of related transporters. This gene should open a route to isolating additional mammalian members of this growing superfamily.

引用

页码：673 / 676

页数：4

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