HALOACETYLATED ENOL ETHERS .4. SYNTHESIS OF 4-TRIHALOMETHYL-2-METHYLTHIOPYRIMIDINES

被引：75

作者：

MADRUGA, CDC ^{[1
]}

CLERICI, E ^{[1
]}

MARTINS, MAP ^{[1
]}

ZANATTA, N ^{[1
]}

机构：

[1] UNIV FED SANTA MARIA,DEPT QUIM,BR-97119900 SANTA MARIA,RS,BRAZIL

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1995年 / 32卷 / 03期

关键词：

D O I：

10.1002/jhet.5570320306

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a series of 5- and 6-substituted 4-trihalomethyl-2-methylthiopyrimidines, prepared from the cyclocondensation reaction of beta-alkoxyvinyl tri[fluoro]chloromethyl ketones with 2-methyl-2-thiopseudourea sulfate, are reported. A systematic study to find the best reaction conditions were carried out.

引用

页码：735 / 738

页数：4

共 11 条

[1] BASE-INDUCED RING CLEAVAGE OF 4-FUNCTIONALIZED 3-UNSUBSTITUTED ISOXAZOLES - SYNTHESIS OF 2-AMINOPYRIMIDINES AND PYRIMIDINE-2(3H)-THIONES [J].

ALBEROLA, A ;

ANTOLIN, LF ;

GONZALEZ, AM ;

LAGUNA, MA ;

PULIDO, FJ .

HETEROCYCLES, 1987, 25 :393-397

[2] HALOACETYLATED ENOL ETHERS .2. SYNTHESIS OF 5-TRIFLUOROMETHYLPYRAZOLES [J].

BRAIBANTE, MEF ;

CLAR, G ;

MARTINS, MAP .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1993, 30 (04) :1159-1160

[3]

Brown DJ, 1984, COMPREHENSIVE HETERO, V3, P57

[4]

COLLA A, 1991, SYNTHESIS-STUTTGART, P483

[5]

Flores A.F.C., 1994, QUIM NOVA, V17, P298

[6] PYRIMIDINES .6. 6-TRIFLUOROMETHYL CHLOROPYRIMIDINES AND RELATED-COMPOUNDS [J].

GERSHON, H ;

GREFIG, AT ;

SCALA, AA .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1983, 20 (01) :219-223

[7]

GERUS II, 1992, CHEM HETEROCYCLIC CO, P398

[8] HALOACETYLATED ENOL ETHERS .3. SYNTHESIS OF 3,3A,4,5,6,7-HEXAHYDRO-3-HALOMETHY[2,1]BENZOISOXAZOLES [J].

MARTINS, MAP ;

FLORES, AFC ;

FREITAG, R ;

ZANATTA, N .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1995, 32 (03) :731-733

[9]

MEYER A, COMMUNICATION

[10] 4-Alkoxy-1,1,1-Trihalo-3-Alken-2-ones as Building Blocks for Trihalomethylated Heterocycles. Synthesis of 4-Trihalomethyl-2-Pyrimidinones [J].

Pacholski, Iraci L. ;

Blanco, Ivani ;

Zanatta, Nilo ;

Martins, Marcos A. P. .

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 1991, 2 (03) :118-120

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