SPECTROPHOTOMETRIC DETERMINATION OF FLUMEQUINE USING IRON(III) CHLORIDE AS A COLOR DEVELOPER

The formation of the complex between flumequine and iron(III) chloride in the pH range 2.0-8.0 was studied. The optimum conditions for this reaction were ascertained and a spectrophotometric method was developed at 384 nm for the determination of flumequine in the concentration range 5-150 mug ml-1, using iron(III) chloride as the reagent. The method is simple, reproducible, and accurate, and is easily applied to the determination of the drug in the pure form and in pharmaceutical preparations. (C) 1994 Academic Press, Inc.