THE EFFECT OF TESTOSTERONE ON THE IMMUNE-RESPONSE .1. MECHANISM OF ACTION ON ANTIBODY-FORMING-CELLS

被引：31

作者：

RIFE, SU

MARQUEZ, MG

ESCALANTE, A

VELICH, T

机构：

[1] Department of Biological Sciences, School of Pharmacy and Biochemistry-University of Buenos Aires, 1113, Buenos Aires

来源：

IMMUNOLOGICAL INVESTIGATIONS | 1990年 / 19卷 / 03期

关键词：

D O I：

10.3109/08820139009041841

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Sex hormones are known to be Implicated in humoral and cellular immune responses. In this study we report the effects of orchidectomy and testosterone replacement on the immune response using T-dependent and T-independent antigens. It was found that the response was dependent on the nature of the antigen employed and on the presence of testosterone. The absence of testosterone receptors in spleen lymphocytes was also found. An hypothesis that testosterone regulates the immune system through the enhancement of suppressive activity is advanced. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：259 / 270

页数：12

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