BIOLOGICAL AND CLINICAL ASPECTS OF INTERLEUKIN-6

被引：1062

作者：

HIRANO, T ^{[1
]}

AKIRA, S ^{[1
]}

TAGA, T ^{[1
]}

KISHIMOTO, T ^{[1
]}

机构：

[1] OSAKA UNIV, BIOMED RES CTR, DIV MOLEC ONCOL, KITA KU, OSAKA 530, JAPAN

来源：

IMMUNOLOGY TODAY | 1990年 / 11卷 / 12期

关键词：

D O I：

10.1016/0167-5699(90)90173-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin 6(IL-6) is a multi-functional cytokine that is produced by a range of cells and plays a central role in host defense mechanisms. Abnormal production of IL-6 has been suggested to be involved in glomerulonephritis, plasmacytomagenesis and in the pathogenesis of autoimmune diseases. In this review, Toshio Hirano and colleagues discuss the possible involvement of IL-6 in a variety of diseases, the regulatory mechanism(s) of expression of the IL-6 gene and the structure and function of the IL-6 receptor.

引用

页码：443 / 449

页数：7

共 73 条

[1] A NUCLEAR FACTOR FOR IL-6 EXPRESSION (NF-IL6) IS A MEMBER OF A C/EBP FAMILY
AKIRA, S
ISSHIKI, H
SUGITA, T
TANABE, O
KINOSHITA, S
NISHIO, Y
NAKAJIMA, T
HIRANO, T
KISHIMOTO, T
[J]. EMBO JOURNAL, 1990, 9 (06) : 1897 - 1906
[2] RECOMBINANT HUMAN B-CELL STIMULATORY FACTOR-II (BSF-2/IFN-BETA2) REGULATES BETA-FIBRINOGEN AND ALBUMIN MESSENGER-RNA LEVELS IN FAO-9 CELLS
ANDUS, T
GEIGER, T
HIRANO, T
NORTHOFF, H
GANTER, U
BAUER, J
KISHIMOTO, T
HEINRICH, PC
[J]. FEBS LETTERS, 1987, 221 (01) : 18 - 22
[3] ASANO S, 1990, BLOOD, V75, P1602
[4] SERUM LEVELS OF INTERLEUKIN-6, A POTENT MYELOMA CELL-GROWTH FACTOR, AS A REFLECT OF DISEASE SEVERITY IN PLASMA-CELL DYSCRASIAS
BATAILLE, R
JOURDAN, M
ZHANG, XG
KLEIN, B
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1989, 84 (06) : 2008 - 2011
[5] A NOVEL FAMILY OF GROWTH-FACTOR RECEPTORS - A COMMON BINDING DOMAIN IN THE GROWTH-HORMONE, PROLACTIN, ERYTHROPOIETIN AND IL-6 RECEPTORS, AND THE P75 IL-2 RECEPTOR BETA-CHAIN
BAZAN, JF
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 164 (02) : 788 - 795
[6] BIONDI A, 1989, BLOOD, V73, P1279
[7] DNA REARRANGEMENT AND CONSTITUTIVE EXPRESSION OF THE INTERLEUKIN 6-GENE IN A MOUSE PLASMACYTOMA
BLANKENSTEIN, T
QIN, ZH
LI, WQ
DIAMANTSTEIN, T
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 171 (03) : 965 - 970
[8] BREEN EC, 1990, J IMMUNOL, V144, P480
[9] EXPRESSION CLONING OF THE MURINE ERYTHROPOIETIN RECEPTOR
DANDREA, AD
LODISH, HF
WONG, GG
[J]. CELL, 1989, 57 (02) : 277 - 285
[10] DEVIERE J, 1989, CLIN EXP IMMUNOL, V77, P221

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