ACTIVITY OF DIHYDROFOLATE-REDUCTASE INHIBITORS ON THE HEPATIC STAGES OF PLASMODIUM-YOELII YOELII INVITRO

被引：10

作者：

ERIKSSON, B

COURTIER, B

BJORKMAN, A

MILTGEN, F

MAZIER, D

机构：

[1] GRP HOSP PITIE SALPETRIERE, INSERM, U313, F-75634 PARIS 13, FRANCE

[2] GRP HOSP PITIE SALPETRIERE, DEPT PARASITOL, F-75634 PARIS 13, FRANCE

[3] MUSEUM NATL HIST NAT, F-75231 PARIS 05, FRANCE

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1991年 / 85卷 / 06期

关键词：

D O I：

10.1016/0035-9203(91)90429-3

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The effects of the dihydrofolate reductase inhibitors proguanil and chlorproguanil, their active metabolites cycloguanil and chlorcycloguanil, and pyrimethamine, against the hepatic stages of Plasmodium yoelii yoelii were investigated in cultured BALB/c mouse hepatocytes. Proguanil was inactive at concentrations of 10(-8) M, whereas the other compounds were fully active at this and lower concentrations. Chlorcycloguanil was the most active compound and almost completely inhibited schizont development in concentrations as low as 10(-12) M.

引用

页码：725 / 726

页数：2

共 14 条

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