EFFECT OF CADMIUM ON BONE REPAIR IN YOUNG-RATS

被引：4

作者：

GUR, E

WANER, T

BARUSHKAEIZIK, O

ORON, U

机构：

[1] TEL AVIV UNIV,DEPT ZOOL,IL-69978 RAMAT AVIV,ISRAEL

[2] LIFE SCI RES ISRAEL LTD,IL-70451 NESS ZIONA,ISRAEL

来源：

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH | 1995年 / 45卷 / 03期

关键词：

D O I：

10.1080/15287399509531994

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The effect of cadmium (Cd) in drinking water on repair of bone at a site of hole injury to the tibia of young rats was followed using quantitative methods. The rats (3-4 wk old) were given 20 ppm and 200 ppm Cd for 5 wk and compared to a control group. A slight reduction (about 10%) in body weight and water and food consumption was observed in cadmium-exposed rats as compared to control rats. Clinical chemistry tests in the blood and histology of kidney, liver, and bone did not indicate changes related to Cd toxicity. A significant reduction (43%) in alkaline phosphatase (AIP) and tartarate-resistant acid phosphatase (TRAP) (46%) enzymatic activity was observed at 4 and 7 d postiniury respectively, in the site of injury in the rats receiving 200 ppm Cd in drinking water as compared to control rats. Calcium accumulation in the newly formed repair tissue at the site of injury was also significantly reduced (53%) at 13 d postinjury in the Cd-treated (200 ppm) rats as compared to control rats. It is concluded that Cd probably exhibits an effect on the bone repair process as reflected by reduction in ALP activity (osteoblastic cells) and mineralization at the site of injury in the tibia of young rats.

引用

页码：249 / 260

页数：12

共 25 条

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