WHY DO ADIPOCYTES MAKE THE BETA(3) ADRENERGIC-RECEPTOR

被引：47

作者：

GRANNEMAN, JG

机构：

来源：

CELLULAR SIGNALLING | 1995年 / 7卷 / 01期

关键词：

ADENYLYL CYCLASE; G-PROTEINS; RECEPTOR REGULATION; BROWN ADIPOSE TISSUE;

D O I：

10.1016/0898-6568(94)00066-K

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Adipocytes express a mixture of beta-adrenergic receptor subtypes, including the recently characterized beta(3) receptor. The co-expression of these subtypes by fat cells suggest they serve different signalling functions. In this review, the properties of recombinant and natively-expressed beta(3) receptors are detailed and contrasted with those of beta(1) and beta(2) receptors. The beta(3) receptor appears to differ from the other beta receptor subtypes with respect to receptor coupling efficiency, G-protein coupling specificity and regulation by agonist exposure. Lastly, the potential of the beta(3) receptor as a therapeutic target is discussed in view of new data regarding its tissue distribution in humans.

引用

页码：9 / 15

页数：7

共 55 条

[1] ATYPICAL BETA-ADRENOCEPTOR ON BROWN ADIPOCYTES AS TARGET FOR ANTI-OBESITY DRUGS [J].