A NOVEL P-TYPE ATPASE FROM YEAST INVOLVED IN SODIUM-TRANSPORT

被引：322

作者：

HARO, R

GARCIADEBLAS, B

RODRIGUEZNAVARRO, A

机构：

[1] Departamento de Microbiologia, Escuela Técnica Superior de Ingenieros Agrónomos

来源：

FEBS LETTERS | 1991年 / 291卷 / 02期

关键词：

SODIUM PUMP; SODIUM ATPASE; SODIUM EFFLUX; LITHIUM EFFLUX; SACCHAROMYCES-CEREVISIAE;

D O I：

10.1016/0014-5793(91)81280-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The gene ENA1 was cloned by its ability to complement the Li+ sensitivity of a low Li+-efflux strain. The nucleotide sequence of the cloned DNA fragment showed that there are two almost identical genes in tandem, and predicts that they encode P-ATPases. Disruption of both genes originated a strain defective in Na+ and Li+ effluxes, and sensitive to Na+, to Li+ and to alkaline pH. By transformation with ENA1 the defective effluxes and tolerances were repaired.

引用

页码：189 / 191

页数：3

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