VISUALIZATION OF CHANGES IN REGIONAL CEREBRAL BLOOD-FLOW (RCBF) PRODUCED BY KETAMINE USING LONG TE GRADIENT-ECHO SEQUENCES - PRELIMINARY-RESULTS

被引：33

作者：

BURDETT, NG

MENON, DK

CARPENTER, TA

JONES, JG

HALL, LD

机构：

[1] Herchel Smith Laboratory for Medicinal Chemistry, Cambridge, CB2 2PZ, Robinson Way

[2] Department of Anaesthesia, University of Cambridge School for Clinical Medicine, Addenbrookes Hospital, Cambridge

来源：

MAGNETIC RESONANCE IMAGING | 1995年 / 13卷 / 04期

关键词：

MRI; FUNCTIONAL IMAGING; REGIONAL CEREBRAL BLOOD FLOW (RCBF); N-METHYL-D-ASPARTATE (NMDA) ANTAGONISTS;

D O I：

10.1016/0730-725X(95)00010-E

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Autoradiographic studies have shown that Low dose ketamine produces increases in regional glucose utilisation and blood flow in the hippocampus, cerebral cortex, and olfactory lobe in the rat brain, probably due to antagonism at the NMDA receptor. Functional MRI using deoxyhaemoglobin contrast can be used to study changes in regional cerebral blood flow (rCBF). Long TE gradient-echo sequences were used to study changes in rCBF produced by low dose ketamine in rats anaesthetised with nitrous oxide, supplemented with either halothane (HAL) or fentanyl/fluanisone/midazolam (FFM) combination. Images from rats in the FFM group showed a 10-14% increase in signal intensity in the hippocampus, cerebral cortex, and olfactory lobe following either a single bolus or a low dose infusion of ketamine (p < .05). These changes were significantly reduced in the HAL group (p < .005). Halothane is known to attenuate the changes in regional glucose utilisation produced by the noncompetitive NMDA antagonist dizocilpine (MK-801), and its effects on ketamine-induced changes in rCBF seen in this study may be due to a similar effect. The potential nse of functional MRI in studying the effect of pharmacological interventions on rCBF is discussed.

引用

页码：549 / 553

页数：5

共 9 条

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