INFLUENCE OF ELECTRICAL-STIMULATION OF THE TIBIALIS ANTERIOR MUSCLE IN PARAPLEGIC SUBJECTS .2. MORPHOLOGICAL AND HISTOCHEMICAL PROPERTIES

被引：91

作者：

ROCHESTER, L ^{[1
]}

BARRON, MJ ^{[1
]}

CHANDLER, CS ^{[1
]}

SUTTON, RA ^{[1
]}

MILLER, S ^{[1
]}

JOHNSON, MA ^{[1
]}

机构：

[1] UNIV NEWCASTLE UPON TYNE,DEPT CHILD HLTH,NEWCASTLE TYNE NE2 4HH,TYNE & WEAR,ENGLAND

来源：

PARAPLEGIA | 1995年 / 33卷 / 09期

关键词：

SKELETAL MUSCLE; MORPHOLOGY; HISTOCHEMISTRY; ELECTRICAL STIMULATION; PARAPLEGIC SUBJECTS;

D O I：

10.1038/sc.1995.112

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In adult paraplegic subjects one tibialis anterior muscle received daily electrical stimulation for 4 weeks at twice the motor threshold to determine changes of morphological and histochemical profiles (this paper) and of contractile properties (preceding paper).(1) Bilateral biopsies, obtained 4 weeks before, and immediately after, electrical stimulation, were studied for fibre type proportions, fibre diameters, oxidative capacity, microvasculature and histopathology. Before stimulation the biopsies showed disuse with increased type 2 fibre proportions and decreased oxidative capacity (succinate dehydrogenase (SDH) activity). The effects of two stimulus patterns(1) were compared. Following stimulation SDH activity increased significantly in all stimulated muscles. Inconsistent changes occurred in fibre type proportions, fibre diameters, capillary density and capillary/fibre ratios. Both stimulus patterns evoked similar results. In five/seven subjects subsarcolemmal vacuolation was observed. Electrical stimulation for 4 weeks at only twice motor threshold improves oxidative capacity, but different stimulus parameters are probably needed for significant fibre type conversion.

引用

页码：514 / 522

页数：9

共 35 条

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