REDUCED SINGLE-DOSE CLEARANCE OF CLOBAZAM IN ELDERLY MEN PREDICTS INCREASED MULTIPLE-DOSE ACCUMULATION

被引:34
作者
GREENBLATT, DJ
DIVOLL, M
PURI, SK
HO, I
ZINNY, MA
SHADER, RI
机构
[1] TUFTS UNIV,NEW ENGLAND MED CTR,DIV CLIN PHARMACOL,BOSTON,MA 02111
[2] HOECHST ROUSSEL PHARMACEUT INC,DEPT CLIN PHARMACOL,SOMERVILLE,NJ 08876
[3] MED & TECHN RES ASSOCIATES INC,NEEDHAM,MA
关键词
D O I
10.2165/00003088-198308010-00005
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:83 / 94
页数:12
相关论文
共 15 条
  • [1] CLOBAZAM - A REVIEW OF ITS PHARMACOLOGICAL PROPERTIES AND THERAPEUTIC USE IN ANXIETY
    BROGDEN, RN
    HEEL, RC
    SPEIGHT, TM
    AVERY, GS
    [J]. DRUGS, 1980, 20 (03) : 161 - 178
  • [2] DRUG-THERAPY - CLINICAL PHARMACOKINETICS .1.
    GREENBLATT, DJ
    KOCHWESER, J
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1975, 293 (14) : 702 - 705
  • [3] SINGLE-DOSE AND MULTIPLE-DOSE KINETICS OF ORAL LORAZEPAM IN HUMANS - PREDICTABILITY OF ACCUMULATION
    GREENBLATT, DJ
    ALLEN, MD
    MACLAUGHLIN, DS
    HUFFMAN, DH
    HARMATZ, JS
    SHADER, RI
    [J]. JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1979, 7 (02): : 159 - 179
  • [4] DRUG-THERAPY - CLINICAL PHARMACOKINETICS .2.
    GREENBLATT, DJ
    KOCHWESER, J
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1975, 293 (19) : 964 - 970
  • [5] DIAZEPAM DISPOSITION DETERMINANTS
    GREENBLATT, DJ
    ALLEN, MD
    HARMATZ, JS
    SHADER, RI
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 1980, 27 (03) : 301 - 312
  • [6] CLOBAZAM KINETICS IN THE ELDERLY
    GREENBLATT, DJ
    DIVOLL, M
    PURI, SK
    HO, I
    ZINNY, MA
    SHADER, RI
    [J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1981, 12 (05) : 631 - 636
  • [7] GREENBLATT DJ, 1982, NEW ENGL J MED, V306, P1081
  • [8] GREENBLATT DJ, 1982, J PHARMACOL EXP THER, V220, P120
  • [9] DEPENDENCE, TOLERANCE, AND ADDICTION TO BENZODIAZEPINES - CLINICAL AND PHARMACOKINETIC CONSIDERATIONS
    GREENBLATT, DJ
    SHADER, RI
    [J]. DRUG METABOLISM REVIEWS, 1978, 8 (01) : 13 - 28
  • [10] ELECTRON-CAPTURE GLC-DETERMINATION OF CLOBAZAM AND DESMETHYLCLOBAZAM IN PLASMA
    GREENBLATT, DJ
    [J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1980, 69 (11) : 1351 - 1352