SELECTIVE DISTRIBUTION OF ACLARUBICIN TO REGIONAL LYMPH-NODES WITH A NEW DOSAGE FORM - ACLARUBICIN ADSORBED ON ACTIVATED CARBON PARTICLES

被引：6

作者：

HAGIWARA, A ^{[1
]}

TAKAHASHI, T ^{[1
]}

IWAMOTO, A ^{[1
]}

YONEYAMA, C ^{[1
]}

MATSUMOTO, S ^{[1
]}

MURANISHI, S ^{[1
]}

机构：

[1] KYOTO COLL PHARMACOL,DEPT BIOPHARMACEUT,KYOTO,JAPAN

来源：

ANTI-CANCER DRUGS | 1991年 / 2卷 / 03期

关键词：

ACLARUBICIN; ACTIVATED CARBON; DRUG DELIVERY SYSTEM; LYMPH NODES METASTASES; TISSUE DISTRIBUTION;

D O I：

10.1097/00001813-199106000-00006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A new dosage form (ACR-CH) comprising aclarubicin adsorbed on activated carbon particles was designed to sustain release of aclarubicin. ACR-CH or aclarubicin aqueous solution (ACR-sol) was injected subcutaneously into the fore foot-pads of rats. ACR-CH distributed a statistically significantly higher level of aclarubicin to the axillary lymph nodes (detectable up to 7 days after injection) than aclarubicin distributed in an ACR-sol (not detectable after 48 h). To other tissues, ACR-CH distributed statistically low levels of aclarubicin, as compared with ACR-sol.

引用

页码：261 / 266

页数：6

共 10 条

[1] BIOPHARMACEUTICAL CONSIDERATIONS IN SUBCUTANEOUS AND INTRAMUSCULAR DRUG ADMINISTRATION [J].

BALLARD, BE .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1968, 57 (03) :357-+

[2]

HAGIWARA A, 1987, ANTI-CANCER DRUG DES, V1, P313

[3]

HAGIWARA A, 1986, ANTICANCER RES, V6, P1005

[4]

HAGIWARA A, 1987, JPN J LYMPHOLOGY, V10, P51

[5]

KITAMURA I, 1987, J ANTIBIOT, V31, P919

[6] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF ACLACINOMYCIN-A AND ITS RELATED-COMPOUNDS .2. REVERSE PHASE HPLC DETERMINATION OF ACLACINOMYCIN-A AND ITS METABOLITES IN BIOLOGICAL-FLUIDS USING FLUORESCENCE DETECTION [J].

OGASAWARA, T ;

MASUDA, Y ;

GOTO, S ;

MORI, S ;

OKI, T .

JOURNAL OF ANTIBIOTICS, 1981, 34 (01) :52-57

[7] NEW ANTITUMOR ANTIBIOTICS, ACLACINOMYCIN-A AND ACLACINOMYCIN-B [J].

OKI, T ;

MATSUZAWA, Y ;

YOSHIMOTO, A ;

NUMATA, K ;

KITAMURA, I ;

HORI, S ;

TAKAMATSU, A ;

UMEZAWA, H ;

ISHIZUKA, M ;

NAGANAWA, H ;

SUDA, H ;

HAMADA, M ;

TAKEUCHI, T .

JOURNAL OF ANTIBIOTICS, 1975, 28 (10) :830-834

[8]

OTA K, 1985, DRUG EXP CLIN RES, V11, P17

[9]

RUSZNYAK I, 1967, LYMPHATICS LYMPH CIR, P49

[10]

TANABE M, 1980, JPN J CANCER RES, V71, P699

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