INHIBITION OF INFLUENZA-A VIRUS HEMAGGLUTININ AND INDUCTION OF INTERFERON BY SYNTHETIC SIALYLATED GLYCOCONJUGATES

被引:64
作者
GAMIAN, A
CHOMIK, M
LAFERRIERE, CA
ROY, R
机构
[1] UNIV OTTAWA,DEPT CHEM,OTTAWA K1N 6N5,ONTARIO,CANADA
[2] POLISH ACAD SCI,LUDWIK HIRSZFELD INST IMMUNOL & EXPTL THERAPY,CZERSKA 12,PL-53114 WROCLAW,POLAND
关键词
INFLUENZA-A VIRUS; SIALIC ACID; INHIBITOR; HEMAGGLUTININ; INTERFERON;
D O I
10.1139/m91-035
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Multivalent forms of neoglycoproteins and polyacrylamides containing sialic acid were prepared and shown to be potent inhibitors of influenza A virus (H3N2) hemagglutinin with chick red blood cells. The synthetic sialylated glycoconjugates, although they were neuraminidase substrates, did not suppress viral neuraminidase and did not reduce infectivities in chick embryos. The copolyacrylamide conjugate containing a spacer group of approximately 11 angstrom (1 angstrom = 0.1 nm) between the polymer backbone and the sialic acid residues was the best hemagglutinin inhibitor. Moreover, it exhibited promising interferon-inducing properties.
引用
收藏
页码:233 / 237
页数:5
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